Daly NL , Craik DJ ( 2009 ). Structural studies of conotoxins . IUBMB Life 61 : 144 – 150 .Daly NL, Craik DJ (2009) Structural studies of conotoxins. IUBMB Life 61: 144-150.Daly N and Craik, D. (2009) Structural Studies of Conotoxins. IUBMB Life; 61:144 150....
This thesis focuses on the study of α-conotoxins, a class of disulfide rich peptides found in the venom of carnivorous marine snails from the genus Possessing an ability to specifically antagonise nicotinic acetylcholine receptors, not only in prey species but also in mammals, these peptides hav...
During our investigation on toxic mussels from the Northern Adriatic sea, initiated about ten years ago, a number of polyether toxins have been isolated an... Patrizia,Ciminiello,Ernesto,... - 《European Journal of Organic Chemistry》 被引量: 108发表: 2004年 Structural studies of conotoxins Co...
23 24 32 27 28 26 29 30 31 Table 1. α-Conotoxins that inhibit α3β4 nAChR. B is 2-aminobutyric acid (Abu), Z is norvaline (Nva), and (*) indicates currents. C-terminal amidation. #Authors do not report an IC50 instead report % inhibition of Ach-evoked studies, we ...
Nicotinic acetylcholine receptors (nAChR) are therapeutic targets for a range of human diseases. α-Conotoxins are naturally occurring peptide antagonists of nAChRs that have been used as pharmacological probes and investigated as drug leads for nAChR re
1995. Characteristics of specific 125I-ω-conotoxin GVIA binding and 125I-ω-conotoxin GVIA labeling using bifunctional crosslinkers in crude membranes from chick whole brain. Biochim. Biophys. Acta 1233:57-67. Google Scholar Ichida, S., Wada, T., Akimoto, T., Kasamatsu, Y., Tahara, ...
Cone snail toxins are well-known blockers of voltage-gated sodium channels, a property that is of broad interest in biology and therapeutically in treating neuropathic pain and neurological disorders. While most conotoxin channel blockers function by direct binding to a channel and disrupting its nor...
Structural characterization of both apo and As(III) bound cysteine-containing designed three-stranded coiled coil peptides and spectroscopic studies to det... DS Touw 被引量: 0发表: 2007年 Structural studies of HIV-1 Tat protein. Tat (trans-activator) proteins are early RNA binding proteins re...
A major caveat to the potential of conotoxins as therapeutics is their susceptibility to in vivo degradation, which limits their effectiveness when delivered orally (Clark, Akcan, Kaas, Daly, & Craik, 2012; Clark et al., 2010). However, the discovery of natural cyclic peptides that are stab...
plantCroton californicuswith antinociceptive effect, and vixotrigine (also known as raxatrigine), which is a state- and use-dependent Nav1.7 blocker under clinical investigation for ameliorating trigeminal pain and neuropathic pain42,43,44. Our present structural studies, along with previous reports,...