Daly NL, Craik DJ (2009) Structural studies of conotoxins. IUBMB Life 61:144-150Daly, N.L.; Craik, D.J. Structural studies of conotoxins. IUBMB Life 2009, 61, 144-150. [CrossRef] [PubMed]N. L. Daly and D. J. Craik, "Structural studies of conotoxins," IUBMB Life, vol. 61,...
Structural studies of conotoxins. NL Daly,DJ Craik - John Wiley & Sons, Ltd 被引量: 0发表: 2009年 Folding of omega-conotoxins. 1. Efficient disulfide-coupled folding of mature sequences in vitro. Disulfide-coupled refolding reactions of five ω-conotoxins, Ca2+ channel antagonists derived ...
During our investigation on toxic mussels from the Northern Adriatic sea, initiated about ten years ago, a number of polyether toxins have been isolated an... Patrizia,Ciminiello,Ernesto,... - 《European Journal of Organic Chemistry》 被引量: 108发表: 2004年 Structural studies of conotoxins Co...
23 24 32 27 28 26 29 30 31 Table 1. α-Conotoxins that inhibit α3β4 nAChR. B is 2-aminobutyric acid (Abu), Z is norvaline (Nva), and (*) indicates currents. C-terminal amidation. #Authors do not report an IC50 instead report % inhibition of Ach-evoked studies, we ...
Previous studies in my lab and others have shown that the didemnid ascidians are a rich source of bioactive peptides, many of which contain cysteine. These cysteine residues in the form of disulfide bridges or five membered heterocyclic rings seem to constrain the peptides to specific conformation...
plantCroton californicuswith antinociceptive effect, and vixotrigine (also known as raxatrigine), which is a state- and use-dependent Nav1.7 blocker under clinical investigation for ameliorating trigeminal pain and neuropathic pain42,43,44. Our present structural studies, along with previous reports,...
F. Li, S.P. Goff Receptor recognition mechanisms of coronaviruses: a decade of structural studies J Virol, 89 (4) (2015), pp. 1954-1964, 10.1128/JVI.02615-14 View in ScopusGoogle Scholar [14] T. Ichimura Y. Mori P. Aschauer K.M. Padmanabha Das R.F. Padera A. Weins et al. ...
α-Conotoxins represent a large group of pharmacologically active peptides that antagonize nicotinic acetylcholine receptors (nAChRs). The α3β4 nAChR, a predominant subtype in the peripheral nervous system, has been implicated in various pathophysiological conditions. As many α-conotoxins have multipl...
However, the biophysical and pharmacological properties of P- and Q-type and recombinant α1A-containing Ca2+ channels do not precisely correlate; this discrepancy might be a result of differences in their structure and subunit composition. Recent studies indicate that the levels of functional ...
The three-dimensional structures of lin-MCoTI and EETI-II were determined from NMR data using the same strategy previously used for structural studies of the cyclic wild type MCoTI-II [26]. The NMR study led to 78 and 71 sequential and 167 and 122 medium and long range NOEs for lin-MC...