RNA binding proteinSECIS elementselenocysteinetranslation3â² UTRIn eukaryotes, the decoding of the UGA codon as selenocysteine (Sec) requires a Sec insertion sequence (SECIS) element in the 3芒聙虏 untranslated region of the mRNA. We purified a SECIS binding protein, SBP2, and obtained ...
through a genome-wide association study, we reveal that natural variations inDROUGHT RESISTANCE GENE 9(DRG9), encoding a double-stranded RNA (dsRNA) binding protein, contribute to drought resistance. Under drought stress, DRG9
Annexin A2 (ANXA2) is a Ca2+-binding protein that is up-regulated in virally transformed cell lines and in human tumors. Here, we show that ANXA2 binds directly to both ribonucleotide homopolymers and human c-myc RNA. ANXA2 was shown to bind specifically to poly(G) with high affinity ...
During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-structured precursors into mature miRNAs. These processing steps can be posttranscriptionally regulated by RNA-binding proteins (RBPs). Here, we have used a proteomics-based pull-down approach to map and characterize...
除了利用m6A-QTL解答了m6A究竟是否调节转录效率的问题,研究人员还观察到相较于control SNPs,m6A QTLs富集于m6A peak内的RRACH motif、RNA 结合蛋白结合位点(RBP binding sites)、RNA二级结构多样性位点(RiboSNitches)以及包含转录因子结合位点(TF binding site)、组蛋白修饰(histone modifications)的转录调控功能区;这提...
This result demonstrates that characterizing the protein corona of various NPs would be a relevant approach to predict their potential toxicological effects. 展开 关键词: Protein corona proteomics silica nanoparticles intrinsically disordered protein RNA binding protein DOI: 10.1080/17435390.2016.1244299 ...
生化机制研究表明,PABPN1一方面通过其N端的内在无序结构域(intrinsically disordered region,IDR)而相互聚集成液态胶体状,与周围环境形成液-液相分离,另一方面通过其C端的RNA结合结构域把具有poly(A)尾的mRNA聚集到以PABPN1为主体的蛋白...
虽然信使RNA (mRNA)已被证明是有效的疫苗,但其作为一般治疗方式的潜力受到其不稳定性和低翻译能力的限制。 2024年3月22日,麻省理工学院化学系/博德研究所王潇及刘如谦(David R. Liu)等团队(陈泓宇为论文的第一作者)合作在Nature Biote...
RNA binding proteins (RBPs) play a fundamental role in posttranscriptional control of gene expression. Different RBPs have oncogenic or tumor-suppressive functions on human cancers.RNPC1belongs to the RNA recognition motif (RRM) family of RBPs, which could regulate expression of diverse targets by...
The polyadenylate binding protein 1 (PABPN1) is a ubiquitously expressed RNA binding protein vital for multiple steps in RNA metabolism. Although PABPN1 plays a critical role in the regulation of RNA processing, mutation of the gene encoding this ubiquitously expressed RNA binding protein causes a ...