A perspective on enzyme catalysis. Science, 301, 1196-1202.S. J. Benkovic and S. Hammes-Schiffer, A perspective on enzyme catalysis, Science, 2003, 301, 1196-1202.Benkovic, S.J. and Hammes-Schiffer, S. (2003) A perspective on enzyme catalysis. Science 301, 1196-1202....
A perspective on biological catalysis We have analysed enzyme catalysis through a re-examination of the reaction coordinate. The ground state of the enzymesubstrate complex is shown to be relat... William,R.,Cannon,... - 《Nat Struct Biol》 被引量: 253发表: 1996年 Revisiting heme mechanisms...
We have analysed enzyme catalysis through a re-examination of the reaction coordinate. The ground state of the enzyme–substrate complex is shown to be related to the transition state through the mean force acting along the reaction path; as such, catalytic strategies cannot be resolved into groun...
enzyme mechanism -a structural perspective structural insights into the evolution of the pantothenate-biosynthesis pathway 来自 dx.doi.org 喜欢 0 阅读量: 11 作者: CMC Lobley,F Schmitzberger,ML Kilkenny,H Whitney,HH Ottenhof,E Chakauya,ME Webb,LM Birch,KL Tuck,C Abell 展开 ...
l-asparaginase (l-ASNase) is an enzyme belonging to the class of amidohydrolases that catalyzes the hydrolysis of l-asparagine into l-aspartic acid and ammonia. It has been widely investigated as a biologic agent for its antineoplastic properties in treating acute lymphoblastic leukemia. The ...
Based on these molecular docking results, experiments based on crystallographic or NMR determination of the enzyme/inhibitor complex are promising. Thus, the next steps of this work will be the cloning, expression, structural resolution and biological assays for functional analysis and application. ...
[30–32]. Since our understanding of themodus operandiof intercellular communication is traditionally limited to cell–cell adhesion conduits and secreted hormones and neurotransmitters, cirDNA may provide a new perspective on how cells communicate and share potentially useful information with each other....
Catalysis in other molybdenum-containing enzymes in the DMSO reductase family is based on the ability of molybdenum to take part in oxo transfer reactions and to exist in the Mo(IV), Mo(V) and Mo(VI) oxidation states [58]. A similar role in catalysis would seem reasonable for both perchl...
Mpro contains an unusually large number of histidine residues, and their protonation states impact enzyme catalysis, substrate binding, and ligand interactions in Mpro45,46. In particular, the neutral state (epsilon protonated) of H163 was shown as critical for maintaining a stable hydrogen bond ...
This perspective considers the idea and the reality of the ‘green’ solvent and explores the search by green chemists for a modern ‘alkahest’. It reviews the characteristics of the ideal solvent, examines the complexities of solvent selection and solvent replacementFootnote1and assesses the likelih...