Enzyme catalysis is a straightforward extension of organic catalysis.Reports on Fred Menger's effort to initiate dialogue between biochemists and organic synthesis chemists.LuberoffBenjaminJ.Chemtech
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers, posing a serious public health challenge that necessitates the development of new therapeutics, therapies, and prevention methods. Among the various therapeutic approaches, interventi
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine1 Ornithine aminotransferase (l-ornithine:2-oxoacid δ-aminotransferase; EC 2.6.1.13), a pyridoxal-5′-phosphate-dependent mitochondrial enzyme controls the ... Paola Storici...
Here, we will refer to all these cell-like systems shortly as synthetic cells (SCs), but most of the discussion will be focused on SCs built from biomolecules as DNA, RNA, ribosomes, enzymes, etc. encapsulated within liposomes. The resulting SCs will function by enzyme catalysis and/or by...
Structural insights into the enzyme catalysis from comparison of three forms of dissimilatory sulphite reductase from Desulfovibrio gigas Mol. Microbiol., 78 (2010), pp. 1101-1116 CrossrefView in ScopusGoogle Scholar [59] K. Parey, E. Warkentin, P.M.H. Kroneck, U. Ermler Reaction cycle of ...
The mutant enzyme displays the ability to form O-, N-, S- and Se- glycosides together with sugar esters and phosphoesters with conversion yields from moderate to high. Analyses also indicate that the pKa of the target compound was the main factor to determine its suitability as glycosylation ...
Benzaldehyde, the simplest aromatic aldehyde, is one of the most wide-spread volatiles that serves as a pollinator attractant, flavor, and antifungal compound. However, the enzyme responsible for its formation in plants remains unknown. Using a combination of in vivo stable isotope labeling, classica...
G. (2000) Threonine 201 in the Diiron Enzyme Toluene 4-Monooxygenase Is Not Required for Catalysis. Biochemistry 39, 791-799.Crystal structure of the ... MH Sazinsky,J Bard,AD Donato,... - 《Journal of Biological Chemistry》 被引量: 255发表: 2004年 Changes in the regiospecificity of ar...
Thus, BciD is a radical SAM enzyme that converts the methyl group of BChlide c or d into the formyl group of BChlide e or f. This probably occurs by a mechanism involving consecutive hydroxylation reactions of the C-7 methyl group to form a geminal diol intermediate, which spontaneously ...
All of the proteins with a TSR domain possess a potential C-mannosylation motif WxxW/C (Fig. 1b) and there is evidence for C-hexosylation of TRAP in sporozoites31,32, implying that a Plasmodium C-glycosyltransferase is expressed throughout the parasite’s lifecycle. The single enzyme likely...