Just relax: A one-pot, three-enzyme chemoenzymatic synthetic approach is highly efficient for obtaining complex sialosides that contain diverse naturally occurring sialic acid modifications. a-2,6-Linked sialosides containing twelve naturally occurring sialic acid forms and seven non-natural sialic ...
(CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. CD22 preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface...
one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of ...
In our well-differentiated cells, α2,6-linked sialic acid is predominantly expressed on the apical surface and the basal cells mainly express α2,3-linked sialic acid. During the whole infection period, release of infectious virus was maintained at a high titre for more than seven days. The...
Expression of α2,3-linked sialic acids and α2,6-linked sialic acids were observed in chicken trachea, whereas α2,3-linked sialic acids were predominant in ducks65,66. Thus, it is possible that the polymorphisms and positive selection detected in position 189 in the HA1 protein were due...
Mice with a mutation in sialate:O-acetyl esterase, an enzyme that specifically removes acetyl moieties from the 9-OH position of α2–6-linked sialic acid, exhibit enhanced B cell receptor (BCR) activation, defects in peripheral B cell development, and spontaneously develop antichromatin ...
The ST6GAL1 sialyltransferase adds an α2,6-linked sialic acid to the termini of N-linked glycans on secretory and membrane glycoproteins (53). We were not able to confirm the reduction of the protein level of ST6GAL1 in miR-199a precursor-transfected cells because an anti-ST6GAL1 Ab ...
(CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. CD22 preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell su...
A switch of viral hemagglutinin receptor binding specificity from bird-type α2,3- to human-type α2,6-linked sialic acid is necessary for an avian influenza virus to become a pandemic virus. In this study, an easy-to-use strip test to detect receptor binding specificity of influenza virus...
By its affinity to α2,3-linked sialic acid, it isinvolved in macrophage binding to different cell types such as granulocytes, monocytes,NK, B and T cells. Several CD169 counter receptors, such as CD227 on human breastcancer cells, CD43 on T cells and CD206 on macrophages, have been ...