Bonasera SJ. 2011. Insights into 5-HT2C Receptor Function Gained from Transgenic Mouse Models In: Di Giovanni G et al , (eds). The Receptors - 5-HT2C Receptors in the Pathophysiology of CNS Disease Humana Press: New York; vol 22, pp51–73.73...
A non-synonymous single nucleotide polymorphism of the human serotonin 5-HTreceptor (5-HTR) gene that converts a cysteine to a serine at amino acid codon 23 (Cys23Ser) appears to impact 5-HTR pharmacology at a cellular and systems level. We hypothesized that the Cys23Ser alters 5-HTR ...
However, there is a lack of focus on the effects of 5-HT2C receptor mutations in disease, such as cancer. To shed light on the function of a potential cancer-driving gene, it is important to illustrate the mutational frequency and their associated biological consequence (Arang and Gutkind, ...
2022年12月19日，贝勒医学院徐勇课题组与剑桥大学Sadaf Farooqi课题组合作在Nature Medicine上发表题为 Human loss-of-function variants in the Serotonin 2C receptor associated with obesity and maladaptive behavior 的研究论文，首次发现5-HT2CR参与调节人类的食欲、体重和行为。首先， 研究人员通过对2548名（46%...
Serotonin 5-HT(2C) receptor protein 5-CSRT task (Robinson et al, 2008). Differences in the sensitivity of the task parameters as well as the tools used to manipulate 5-HT2CR function (genetic vs pharmacological) most likely underlie the discrepancies between the present study and previous ...
5-HT2C receptors have been shown to modulate mesolimbic dopaminergic function, where they exert a tonic inhibitory influence over dopamine neurotransmission. The 5-HT2C receptor knockout mouse suffers from spontaneous convulsions, cognitive impairment, increased food intake, and obesity, but similar ...
Isaac M .The 5-HT2c receptor as a potential therapeutic target for the design of antiobesity and antiepileptic drugs [J ] .Drugs F uture ,2001 ,26 (4 ) :389 —393 . [2 ] Barnes NM ,S harp T .A renew of central 5.HT rec eptors and their function[J ] .Neuropha rmacolog...
Moorman JM, Leslie RA (1996) P-chloroamphetamine induces c-fos in rat brain: a study of serotonin2A/2C receptor function. Neuroscience 72(1):129–139 PubMed CAS Google Scholar Mostofsky SH, Simmonds DJ (2008) Response inhibition and response selection: two sides of the same coin. J ...
受体激动剂m-氯苯基哌嗪(mCPP)已被证明可减少人类的慢波睡眠(Decreased Tryptophan Availability but Normal Post-Synaptic 5-HT2C ReceptorSensitivity in Chronic Fatigue Syndrome;Vassallo,C.M.等人,Psychologicalmedicine(2001),31(4),585-91)。 尿失禁 血清素能系统已广泛涉及膀胱功能的控制。已经证明,表达5-HT...
[ 4] Barnes, NM. , Shar, T. A review of central 5HT receptor and their function. Neuropharmacology, 1999, 38: 1083 1152. [5] LiewCJ, Lim YM, Bonwetsch R, et a.l 18F FCWAY and 18F FDG PET in MRI negative temporal lobe epilepsy. Epilepsia, 2009, 50: ...