To address this question, we assessed the inhibition of 5-HT turnover by a 5-HT2C receptor agonist (RO 60-0175) at the hippocampal level and under conditions of stress, after pharmacological or genetic inactivation of either GABA-A or GABA-B receptors in mice. Neither the GABA-B receptor ...
已经证明,兔中表达5-ht3和5-ht4受体的神经节前纤维和神经节血清素能神经元及表达5-ht1和5-ht2受体的效应器平滑肌细胞积极参与膀胱收缩活动的调节(roleofserotoninreceptorsinregulationofcontractileactivityofurinarybladderinrabbits;lychkova,a.e.andpavone,l.m.,urology2013mar;81(3):696)。此外,在文献中支持...
Moorman JM, Leslie RA (1996) P-chloroamphetamine induces c-fos in rat brain: a study of serotonin2A/2C receptor function. Neuroscience 72(1):129–139 PubMed CAS Google Scholar Mostofsky SH, Simmonds DJ (2008) Response inhibition and response selection: two sides of the same coin. J ...
5一HT2creceptor;obesity;drugabuse;epilepsy 5一羟色胺(5一HT或serotonin)是中枢及外周神 经系统的重要神经递质。研究发现,它涉及人类的 感觉、运动和行为等许多生理过程。这些不同的生 理效应与广泛分布在脑组织内的5一HT能神经节以 及5一HT的许多不同的受体亚型有关。迄今为止, 在人类的中枢神经系统至少发现...
Berg KA, Clarke WP, Cunningham KA, Spampinato U (2008a) Fine-tuning serotonin2c receptor function in the brain: molecular and functional implications. Neuropharmacology 55:969–976 Article CAS PubMed PubMed Central Google Scholar Berg KA, Dunlop J, Sanchez T, Silva M, Clarke WP (2008b) ...
We next adopted a chemogenetic approach using a 5-HT2CRCRE line to clarify the function of subset of 5-HT2C receptor expressing VTA neurons in the modulation of appetite and food-motivated behavior. Activation of VTA 5-HT2C receptor expressing neurons significantly reduced ad libitum chow intake...
受体激动剂在肥胖和2型糖尿病小鼠模型中显著改善葡萄糖耐受性并降低血浆胰岛素,激动剂浓度为对摄食行为、能量消耗、运动活动、体重或脂肪量无影响(Serotonin 2C Receptor Agonists Improve Type 2 Diabetes via Melanocortin-4Receptor Signaling Pathways;Ligang,Z.等人,Cell Metab.2007年11月7日;6(5):398-405)。
Any 5-HT2C receptor-induced increase in GABA- variety of reinforcers, and are not selective for cocaine. In ergic function is likely to be nonselective in that the release the present experiments, Ro60-0175 injected into the VTA of GABA could activate both GABA-A and GABA-B also ...
These approaches manipulate the expression of the receptor, not POMC production. We aimed to determine the function of POMC in lorcaserin's anorectic effect. As a first step toward this goal, we employed a mouse model with full POMCARC knockout and approximately half POMCNTS knockdown (PomcNEO...
GABA A receptors5-hydroxytryptamine5-HT 2C receptorsXenopus oocytesphosphorylationG proteinTwo classical neurotransmitters, 5-hydroxytryptamine (5-HT) and GABA, coexist in neurons of the medulla oblongata, and activation of 5-HT receptors modulates GABA A receptor function in neurons of the ventral ...