function such as the prefrontal cortex, entorhinal and pyriform cortex,claustrum, nucleus accummbens, andhippocampus(see[7]). Converging evidence from a variety of studies indicates that the 5HT2Areceptor may be uniquely important as a therapeutic target inschizophreniasince it appears to play a ...
The 5-HT2A receptor ("5-HT" = 5-hydroxytryptamine, also known as serotonin) is a widely-expressed Gq-coupled protein receptor (GCPR) that triggers a range of intracellular pathways. In this article, we will explore everything scientists know so far about the location, function, and ...
However, the important question is whether upregulation of the receptor is a consequence of the disease or the 5HTreceptor is involved, at least partly, in the development of the disease. In order to study the link between 5HTreceptor and behavior, we have generated receptor deficient knock-...
5-HT2A, a G-protein coupled receptor, is widely expressed in the human body, including in the gastrointestinal tract, platelets and the nervous system. It mediates various functions, for e.g. learning, memory, mood regulation, platelet aggregation and va
Serotonergic psychedelics possess considerable therapeutic potential. Although 5-HT2A receptor activation mediates psychedelic effects, prototypical psychedelics activate both 5-HT2A-Gq/11 and β-arrestin2 transducers, making their respective roles uncle
Ebselen and lithium were administered either acutely or chronically prior to assessment of 5-HT 2A receptor function. Given the SSRI augmenting action of lithium and 5-HT 2A antagonists, ebselen was also tested for this action by co-administration with the SSRI citalopram in microdialysis (...
[0533] Marcos,B.,García-Alloza,M.,Gil-Bea,F.J.,Chuang,T.T.,Francis,P.T., Chen,C.P.,Tsang,S.W.T.Y.,Lai,M.K.P.,Ramirez,M.J.,2008.5-HT-{6}受体功能的改变 与阿尔茨海默氏病的行为症状有关.(Involvement of an altered 5-HT-{6}receptor function in ...
The goal of this study was to develop a suitable kinetic analysis method for quantification of 5-HT2A receptor parameters with [11C]MDL 100,907. Twelve control studies and four preblocking studies (400 nmol/kg unlabeled MDL 100,907) were performed in isoflurane-anesthetized rhesus monkeys. The...
Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA. Serotonin (5-HT) release is the primary pharmacological mechanism of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') action in the primate brain. Dopam... Heffter,F.,Hasler,... - 《Journal of Psychopharma...
Introduction [ 11 C]MDL100907 is a high affinity PET ligand for 5-HT2A receptor quantification in vivo. On the basis of ROI analysis, the tracer is usually assumed to be reversible as its kinetics are well described by a two-tissue four-rate constant model [1]. In literature [ 11 C]...