Pharmaceutical compositions of the invention comprise functionalized lactone derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.Benjamin E. BlassDaniel J. Canney...
Based on the rank order potency of the agonists and antagonists, one of the receptors that mediates the decrease in sAHP amplitude in CA3 hippocampal pyramidal cells was concluded to be the 5-HT(7) receptor. 展开 关键词: Pyramidal Cells Receptors Serotonin serotonin-7-receptor Serotonin Agonists...
Downregulation of 5-hydroxytryptamine(7) receptor in the medial prefrontal cortex ameliorates impulsive actions in animal models of schizophreniaSchizophreniaMedial prefrontal cortexPhencyclidineImpulsivityR mRNA in the mPFC was significantly decreased to
血清素受体可分为七个亚科 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7。至少有十四种受体亚型已被发现,包含G蛋白偶联受体和配体门控离子通道(G protein-coupled receptor and a ligand-gated ion channe)。5-HT1受体是5-HT受体家族中最庞大的一科,目前有5种亚型:A、B、D、E、F。5-...
7.5-hydroxytryptamine-3 receptor亚型受体 用法例句 1. Methods Rats were injected intradermally with 2%5-hydroxytryptamine(5-ht) on the nape of the neck. 方法大鼠颈背部皮内注射2% 5 -羟色胺(5 - HT)建立大鼠瘙痒模型。 2. The results indicated that the CMC method could be a new way for quant...
5-HT1A receptor Agonist5-HT1B receptor Agonist5-HT1D receptor Agonist5-ht1e receptor Agonist5-HT1F receptor Agonist5-HT2A receptor Agonist5-HT2B receptor Agonist5-HT2C receptor Agonist5-HT3A Agonist5-HT3AB Agonist5-HT4 receptor Agonist5-HT5A receptor Agonist5-HT6 receptor Agonist5-HT7 ...
5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates In the last few years, molecular biology has led to the cloning and characterization of several 5-HT receptors (serotonin receptors) in vertebrates and in ... F Saudou,R Hen - 《Neurochemistry International》 被引量: 333发表:...
We have reported recently that the mouse 5-hydroxytryptamine(4a) (5-HT4(a)) receptor undergoes dynamic palmitoylation (Ponimaskin, E. G., Schmidt, M. F., Heine, M., Bickmeyer, U., and Richter, D. W. (2001) Biochem. J. 353, 627–663). In the present study, conserved cysteine ...
By reverse transcription (RT) and PCR, messenger RNA (mRNA) expression of 5-HT receptor 1E (5-HTR1E), 5-HTR2A, 5-HTR3, 5-HTR4 and 5-HTR7 could be revealed. Functional studies showed that 5-HT modulates the release of IL-1β, IL-6, IL-8/CXCL8, IL-12p40 and tumor necrosis...
Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine Depression is associated with abnormal neuronal plasticity. AMPA receptors mediate transmission and plasticity at excitatory synapses in a manner which is ... P Svenningsson,H Bateup,H Qi,... - 《...