英文名:5-HT;5-Hydroxytryptamine;Serotonin hydrochloride;5-HT receptor agonist CAS号:153-98-0 结构式:c1cc2c(cc1O)c(c[nH]2)CCN.Cl 分子式:C10H12N2O·HCl 分子量:212.68 熔点:168-172°C 密度:1.0200 溶解度:溶于水 (17 mg/ml)、甲醇、乙醇 (5.3 mg/ml)、0.1 M HCl (22 mg/ml)、酸...
5-HT receptor agonists and antagonists used for various assays, some have entered clinical trials, which would be new cancer therapies.
ABBREVIATIONS: nAChR, nicotinic acetylcholine receptor; ACh, acetylcholine; SSR180711, (1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid, 4-bromophenyl ester; A-582941, 2-methyl-5[6-phenylpyridazin-3-yl]octahydropyrrolo[3,4-c]pyrrole; PAM, positive allosteric modulator; PNU-120596, 1-(5-chl...
Section > Chapter Hirth, I.C.; Deitmer, J.W. Glia 54(8): 786-794 2006 ISSN/ISBN:0894-1491 16958089 10.1002/glia.20417 011673487 Full-Text Article emailed within 0-6 h Buy Now for$19.90 Payments are secure & encrypted Abstract
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Article: 5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease
Among the tested compounds, several were potent and efficacious 5-HT(2C) receptor agonists with selectivity over both 5-HT(2A) and 5-HT(2B) receptors in functional assays. The most promising compound is 37, with 120- and 14-fold selectivity over 5-HT(2A) and 5-HT(2B), respectively (...
Phospholipase D activation was measured in primary cultures of rat choroid plexus epithelial cells, which endogenously express the 5-hydroxytryptamine (5-HT) 2C receptor, as well as a heterologous cell line expressing the cloned receptor. In both systems, serotonin stimulation of the 5-HT2C recepto...
The 5-hydroxytryptamine (5-HT)1B/1D receptor subtypes are involved in the regulation of 5-HT release and have gained particular interest because of their apparent role in migraine. Although selective antagonists for both receptor subtypes recently have been developed, the receptor domains involved in...
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