5-Hydroxytryptamine1D-like receptors mediate contraction of partially depolarized rabbit renal arteries.AnimalsRabbitsRenal ArterySerotoninSerotonin AntagonistsReceptors, SerotoninMuscle ContractionSerotonin Receptor AgonistsMaleThis study characterizes the 5-hydroxytryptamine (5-HT) receptors involved in the ...
1The effects of 5-hydroxytryptamine (5-HT) and of the 5-HT1-like receptor agonists, 5-carboxamidotryptamine (5-CT) and sumatriptan (GR43175) were investigated in isolated ring preparations of guinea-pig common iliac artery.2The three agonists induced very weak, if any, contractions of ...
Serotonin receptors, other than 5-HT3 subtype belong to the super-family of G-protein coupled receptors.nThe 5-HT3 receptor is formed by five subunits arranged around a pore forming unit. Receptors could be either monomeric, such as 5-HT3A or heteromeric entities like 5-HT3A/B. Indeed,...
1We describe the actions of GR43175, a 5-hydroxytryptamine1 (5-HT1)-like receptor agonist, on neurogenically-mediated plasma protein extravasation within a... MG Buzzi,MA Moskowitz - 《British Journal of Pharmacology》 被引量: 148发表: 2012年 Neuroeffector functions of sensory fibres: implicatio...
5-HT(2A) receptorDeep layers of the superior colliculusDefensive behaviourFear-induced antinociceptionPanic disorderMicroinjections of N-methyl-d-aspartic acid (NMDA) in the midbrain tectum structures produce panic attack-like defensive behaviours, followed by an antinociceptive response. It has been ...
It can potently activate TrkB receptor. 体外活性 N-Acetyl-5-hydroxytryptamine 以昼夜节律方式激活TrkB受体。N-Acetyl-5-hydroxytryptamine迅速且昼夜节律地激活TrkB,并以TrkB依赖的方式呈现抗抑郁效应。N-Acetyl-5-hydroxytryptamine能快速激活TrkB,但不激活TrkA或TrkC,并且这一过程不依赖神经营养因子和MT3受体[1]。
Receptor subtypes 5-HT2Cand 5-HT1Aare implicated in the inverted U-shaped dose-response curves of HTR and locomotor activity induced by DOM in mice. The biphasic dose-response function of HTR and locomotor activity induced by DOM has different mechanisms in mice. ...
Selective 5-Hydroxytryptamine 2C Receptor Agonists Derived from the Lead Compound Tranylcypromine: Identification of Drugs with Antidepressant-Like Action 来自 Semantic Scholar 喜欢 0 阅读量: 78 作者:SJ Cho,NH Jensen,T Kurome,S Kadari,ML Manzano,JE Malberg,B Caldarone,BL Roth,AP Kozikowski ...
Thus, an association has been described between C267T polymorphism of the 5-hydroxytryptamine 6 receptor (5-HT(6)) receptor gene and AD. This case-control study analyzes the ApoE and 5-HT(6) receptor polymorphisms in 173 cases and 102 age and sex matched controls from Araba and Bizkaia (...
CP 93129, a selective 5-HT1B receptor agonist, depressed the fast IPSC. The 5-HT-induced depression of the fast IPSC was attenuated by SB 216641, a selective antagonist for 5-HT1B receptors. 5-HT did not change the inward currents mediated by GABAA receptors, suggesting that 5-HT ...