Helix 1 lies in the target groove against the other helices, but is displaced 3 along the bundle axis. This result highlights the potential of computational design to create bundles with atomic-level precision, but also points at remaining challenges for achieving specific positioning between ...
Template-assembled synthetic 4-helix bundle protein The cerebellar contribution to cognitive operations and emotional behavior is critically dependent upon the existence of plausible anatomic substrates. Thi... M Mutter,G Tuchscherer - 《Die Makromolekulare Chemie Rapid Communications》 被引量: 244发表:...
TheproteinFelixwasdesigneddenovotofoldintoanantiparallelfour-helixbundleofspecifictopologyItssequenceof79aminoacidresiduesisnothomologoustoanyknownproteinsequence,butis"native-like"inthatitisnonrepetitiveandcontains19ofthe20naturallyoccurringaminoacidsFelixhasbeenexpressedfromasyntheticgeneclonedinEscherichiacoli,andthe...
The 14-bundle design of Complement4 expands to 30 bundles arranged into six subgroups; Prion contains more than double the amount of OCC silver as Complement4. The ultrapure single-crystal OCC silver litz bundles are arrayed into a cylindrical-tube layout inside each Complement4 Integrated Wire. ...
2001. HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process. Biochemistry 40:12231-12236. http: //dx.doi.org/10.1021/bi0155596.Gallo S, Puri A, Blumenthal R. HIV-1 gp41 six-helix bundle formation occurs...
Far Cry 4 + Far Cry Primal Bundle 199₪ 76 notifications Alert favorite Like add_circle To Lib visibility_off Hide Middle-Earth: Shadow Of Mordor -Game Of The Year Edition 239₪ 84 notifications Alert favorite Like add_circle To Lib visibility_off Hide Assassin's...
aClose to the N-terminus, the highly structured DBD is the most conserved part of Hsfs. It consists of a 3-helical bundle (H1, H2, H3) and a 4-stranded antiparallel bsheet (b1, b2, b3, b4). The hydrophobic core of this domain ensures the precise positioning of the central helixturn...
Electron transfer activity of a de novo designed copper center in a three-helix bundle fold J.S. Plegaria, et al., Electron transfer activity of a de novo designed copper center in a three-helix bundle fold, Biochim. Biophys. Acta 1857 (5... Quaranta,Annamaria,Plegaria,... - 《...
Yummy is the first word that comes to mind, followed by sounds of lip smacking. It’s a rich bundle of extracted cherry and raspberry fruit, driven deep with juicy acidity, and bound with ripe tannins. The penetration and vivid tartness are remarkable, and supremely satisfying.——P.G.(11...
Experimental evidence for a frustrated energy landscape in a three-helix-bundle protein family. Energy landscape theory is a powerful tool for understanding the structure and dynamics of complex molecular systems, in particular biological macromolecul... BG Wensley,S Batey,FAC Bone,... - 《Nature》...