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In HX Edit, applying a custom color to a Snapshot footswitch can sometimes not be reflected on the hardware. For now, apply snapshot footswitch colors from the hardware In HX Edit, if the current preset has not been saved, importing a different preset, setlist, or bundle does not currentl...
bundle of His A bundle of small specialized conducting muscle fibres in the mammalian heart that is responsible for transmitting electrical impulses from atrium to ventricle. bungarotoxins Toxins found in the venom of Bungarus multicinctus, the multi-banded krait. Alpha-bungarotoxin (74aa) causes vir...
2b). In contrast to the AH region, the C-terminus of Plin4 containing the predicted 4-helix bundle was completely cytosolic (Supplementary Fig. 2c). The experiments presented so far were performed on fixed cells, and we found that fixation itself augmented Plin4 AH targeting to LDs, ...
S0 spans across the SR membrane, adjacent to the RyR1 S1-S4 helix bundle, enhances the coupling between pVSD and S4/S5 linker and exerting a pulling force on S6 to facilitate pore open. In our structure model, Ca2+ regulating the channel opening through α4/U motif-VSC following with p...
(Figure6). According to this scheme, the trigger loop base helices are delicately balanced on the verge of instability and require bridge helix residues nearby in order to form a stable three-helix bundle (Figure6a,b; Additional data file21). If these interactions are disrupted by mutations (...
Thus, the four-helical bundle remains intact, and the helices maintain the same register. This is not compatible with two wide-spread models for HAMP activity, one proposing a piston motion of the helices perpendicular to the plane of the membrane, which requires changes in the helical register...
Large variations in shape and in tilt angles of the helices relative to the membrane plane are found in both the α1-subunit (Figures 6 and 7) and in PE-NMT (Figure 9). Other investigators have shown that transmembrane helices may be tilted and packed within the helical bundle and thus ...
(Fig.2b, Supplementary Table2). Specifically, five predicted fold switchers had RfaH-like CD spectra with minima at 208 nm, a characteristic feature of helical folds that suggests ground-state helical bundle conformations in two RfaHs (variants #2, #6), a LoaP (variant #1), an annotated...