DPG also prevented the inactivation of HMG-CoA reductase by ATP and Mg ++ . Rat liver microsomal HMG-CoA reductase prepared in the presence of 1 mM DPG was significantly more active than when prepared in the absence of DPG. Activation of the enzyme by DPG and protection of the enzyme ...
3-HYDROXY-3 METHYL GLUTARYL COENZYME A (HMG COA) REDUCTASE ACTIVITY IN FIBROBLASTS FROM PHENOTYPIC HOMOZYGOUS TYPE II HY-PERLIPOPROTEINEMIA (HHLPII)Pediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, ...
Recombinant HMGRThe enzyme 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGR) is a glycoprotein of the endoplasmic reticulum that participates in the mevalonate pathway, the precursor of cholesterol in human and ergostdoi:10.1007/s12010-017-2412-9Andrade-Pavón, Dulce...
To fulfill this aim, we have carried out a molecular docking study toward 3‐hydroxy‐3‐methyl‐glutaryl‐CoA (HMG‐CoA) reductase. A set of designed structural derivatives of statin drugs, eight ligands which are used as HIV‐1 integrase inhibitor candidates, a set of terpenoids, and ...
3P-0644 New 3-hydroxy-3 methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor, pitavastatin has biphasic effect on angiogenesis - Atherosclerosis Supplementsdoi:10.1016/S1567-5688(03)90864-6M. KatsumotoT. ShinguR. KuwashimaS. NomuraK. Chayama...
Context: 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors, also called as statins are widely used to treat dyslipidaemia which is a significant risk factor for cardiovascular diseases. The importance of pharmaco economic studies are increasing due to explosion of new drugs in ...
In HepG2 cells treated with 400 g/mL ELE, the expression of 3-hydroxy-3-methyl-glutaryl-CoA reductase decreased markedly (45%; P < 0.05), whereas that of the LDL receptor increased (230%; P < 0.05). The protein levels of both were altered similarly. The ELE also increased membrane-...
Simvastatin, an inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase, inhibits the insulin secretagogues-induced cytosolic Ca2+ activities in rat pancreatic β-cellsdoi:10.1016/0021-9150(94)93969-1T. YadaAtherosclerosis
The principal enzyme of the cholesterol pathway is the 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR). Our aim is to study whether defects of HMGCR function would produce orofacial malformation similar to those found in disorders of cholesterol synthesis.Signore, Iskra A.Jerez, CarolinaFigueroa,...
In HepG2 cells treated with 400 µg/mL ELE, the expression of 3-hydroxy-3-methyl-glutaryl-CoA reductase decreased markedly (45%; P < 0.05), whereas that of the LDL receptor increased (230%; P < 0.05). The protein levels of both were altered similarly. The ELE also ...