In the MVA pathway, 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) catalyzes the condensation of acetoacetyl-CoA and acetyl-CoA to form 3-hydroxy-3-methylglutaryl-coenzyme A. Our previous studies had shown that, while the recombinant Brassica juncea HMGS1 (BjHMGS1) mutant S359A displayed 10-...
This study demonstrates that ethanol consumption increases the formation of a 4-HNE adduct with mitochondrial HMG-CoA synthase, which has the potential to inactivate the enzyme in situ. 展开 关键词: HMG-CoA synthase 4-HNE Mitochondria Chronic ethanol ...
β-hydroxybutyrate production is regulated by the enzyme 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) in the mitochondria. HMGCS2 catalyzes the rate-limiting conversion of acetoacetyl-CoA and acetyl-CoA into 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA), which is further converted into acetoacetate...
本研究采取新生犊牛肝细胞原代培养方 法,检测外源性BHBA对HMGCS基因表达水平的 影响,进一步探讨BHBA对奶牛肝脏脂肪酸氧化 代谢途径的影响。 1材料与方法 1.1主要试剂 琼脂糖、Tris、蛋白胨、酵母提取物、TaqDNA BHBA对体外培养犊牛肝细胞HMGCS 基因表达的影响 ■李鹏 1 刘敏跃 2 龙淼 1 郭洋 1 王哲 3 何剑斌 1 ...
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells. cAMP increases transcription of the mitochondrial (mit.) gene for 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase, which encodes an enzyme that has been prop... ...
3-Hydroxy-3-methylglutaryl Coenzyme A Synthase coenzyme A synthase, which catalyzes the condensation of acetyl-CoA with acetoacetyl-CoAto form 3-hydroxy-3-methylglutaryl- CoA, also carries out: (a) a rapid transacetylationfrom acetyl- CoA to 3'-dephospho-CoAand (b) a slow hydrolysis ... ...
Plant 3-hydroxy-3-methylglutaryl-CoA reductase(HMGR; EC 1.1.1.34) and sucrose-phosphate synthase (SPS; EC 2.4.1.14) and synthetic peptides designed from th... D Toroser,SC Huber - 《Archives of Biochemistry & Biophysics》 被引量: 129发表: 1998年 Ubiquitination of 3-Hydroxy-3-methylglutaryl...
lt;ranGsfTe—ragsely, coβs-yAltSr—anbsfeetraa-saem; yrUinGTsy—nUthDasPe-; gClAycSo—syclytrcalonasrfeternasoel,syβn-tAhaSs—e;bLeSta—-almanyorsitneroslysnytnhtahsaes; e;CLAUSS——clyucpleooalrtseynnotlhassye.nSthoalisde;redL-Sf—ralmaneomsteearnosl synthase; LUS—lupeol synthase....