In the MVA pathway, 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) catalyzes the condensation of acetoacetyl-CoA and acetyl-CoA to form 3-hydroxy-3-methylglutaryl-coenzyme A. Our previous studies had shown that, while the recombinant Brassica juncea HMGS1 (BjHMGS1) mutant S359A displayed 10-...
本研究采取新生犊牛肝细胞原代培养方 法,检测外源性BHBA对HMGCS基因表达水平的 影响,进一步探讨BHBA对奶牛肝脏脂肪酸氧化 代谢途径的影响。 1材料与方法 1.1主要试剂 琼脂糖、Tris、蛋白胨、酵母提取物、TaqDNA BHBA对体外培养犊牛肝细胞HMGCS 基因表达的影响 ■李鹏 1 刘敏跃 2 龙淼 1 郭洋 1 王哲 3 何剑斌 1 ...
Control of hepatic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase during the foetal/neonatal transition, suckling and weaning in the rat 1We assayed active and total (i.e. active plus succinylated) 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase in mitochondria isolated from foetal, neona...
Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3-methylglutaryl (HMG-CoA) synthase Chronic ethanol consumption causes increased production of reactive oxygen species in hepatic mitochondria accompanied by elevations in products of lipid p... Vinood B. Patel and Christina H. Spencer and Tracey...
SIRT3 Deacetylates Mitochondrial 3-Hydroxy-3-Methylglutaryl CoA Synthase 2, Increases its Enzymatic Activity and Regulates Ketone Body Production SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 2010 Dec 1;12(6):654-61... ...