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This study describes the extraction and characterization of an inhibitor for beta-hydroxy-beta-methylglutaryl (HMG) coenzyme A (CoA) reductase from Puerari... HJ Kim,DH Lee,YY Hwang,... - 《Journal of Agricultural & Food Chemistry》 被引量: 9发表: 2005年 Calcium beta-hydroxy-beta-methylbutyr...
(1976): Michaelis- Menten Constant for HMG CoA reductase: Demons- tration of a substrate affinity 10-fold greater than previously reported. /. Biol Chem. 251: 5820- 5823.Langdon, R. B. and R. E. Counsell (1976). "Determination of the Michaelis- Menten constant for beta-hydroxy-beta-...
Nepokroeff CM, Lakshmanan MR, Ness GC, Dugan RE, Porter JW. Regulation of the diurnal rhythm of rat liver beta- hydroxy-beta-methylglutaryl coenzmye A reductase activity by insulin, glucagon, cyclic AMP and hydrocortisone. Arch Biochem Biophys 1974; 160: 387-396...
Disclosed is a combination of at least two components selected from the group consisting of: (i) a (3-hydroxy-(3-methylglutaryl-co-enzyme-A reductase (HMG GoA reductase) inhibitor or a pharmaceutically acceptable salt thereof, selected from the group consisting of atorvastatin, cerivastatin, ...
Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), statins, which are used to prevent cardiovascular diseases, are associated with a modest increase in the risk of new-onset diabetes. To investigate the role of HMGCR in the development of beta-cells and glucose homeostasis, we ...
The lanosterol demethylation intermediate 3 beta-hydroxylanost-8-en-32-al is a known suppressor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), the rate-limiting enzyme of cholesterol biosynthesis. Studies on the mechanism of action of this compound have been hampered by its rapid ...
Boots, M.R., et al., 1973, " Hypocholesterolemic Agents II: Inhibition of beta-Hydroxy-beta-Methylglutaryl Coenzyme A Reductase by Arylalkyl Hydrogen Succinates and Glutarates ", J. Pharm. Sci., vol. 62, No. 6, pp. 952-957.
Favata et al., “Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15αfluorolanost-7-en-3β-ol. A mechanism-based inhibitor of cholesterol biosynthesis - Trzaskos, Magolda, et al. - 1993 () Citation Context ... hepatic HMG-CoA reductase in CHO cells [26]. The structural ...
The 25-aza analog (VII) of the 15-ketosterol (I), at a concentration of 1.0 microM, caused a 47% lowering of the level of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in Chinese hamster ovary cells.doi:10.1016/0009-3084(91)90015-4Josef E. Herz...