分分类号: R734.2 学校代码:1 0 0 6 2 密密 级: 学 号: 2012601091学位类别: 科学学位□ √ 专业学位 学科门类: 医学 博 士士学位论文 DOCTORAL DISSERTATION 论文题目: 糖酵解抑制剂 2-DG 抑制 ERK 磷酸化的分子机制 T I T L E Molecular mechanism by which the glycolysis inhibitor 2-DG ...
2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity. 体外活性 方法:胰腺癌细胞 MIA PaCa2、BxPC-3、ASPC-1 和卵巢癌细胞 OVCAR-3、HEY、SK-OV-3 用 ...
and tumorigenicity of the cells expressing different levels of ZBTB7A were tested by adding the glycolysis inhibitor 2-deoxy-D-glucose(2-DG),followed by MTT,colorimetric focus forming,and xenograft assays,respectively.Our results showed that high expression of GLUT1 was associated with late-stage ...
Graphical Summary of Metabolic Reprogramming of HSCs in Lung Cancer: Impact of 2-DG-Mediated Glycolysis Inhibition on the Immune Microenvironment Full size image Continuing the exploration of this study, these findings are not only scientifically significant, particularly in understanding the impact of th...
NS NS;NS-398;CS-2231;NS-398 98%;Taisho NS 398;NS-398 (NS 398;NS-398 USP/EP/BP;glycolysis inhibitor;NS-398, 10 mM in DMSO;NS 398, COX-2 inhibitor 中文名: 抑制剂 中文别名: 抑制剂;化合物NS398;NS-398抑制剂;NS-398(COX-2抑制剂);COX-2选择性抑制剂NS-398;化合物NS398,10 MM ...
glycolysis were significantly downregulated when TLR2 was deficient, which were confirmed by lung protein immunoblots. Glycolysis inhibitor 2-Deoxy-d-glucose (2-DG) inhibited allergen-induced airway inflammation, pyroptosis, oxidative stress and glycolysis in wild type (WT) mice, while hif1α ...
将共同靶点与中药有效成分 代入 Cytoscape 3.72 进行可视化分析,通过 Network Analyzer 分析度值,中心度值及亲中心度值,筛选 出前 5 位中药有效成分为核心成分:山柰酚 ( kaempferol , HQ10 , 来源于黄芪 ), 槲皮素 (quercetin,HQ13,来源于黄芪),顺式阿魏酸(cis- ferulic acid , DG5 , 来源于当归 ), 洋...
中图分类号R742.1UDC610博士学位论文学校代码!Q§3三密级公珏糖酵解抑制剂2.脱氧葡萄糖抗痫作用机制研究Themechanismofantiepi..
resulting in increased glycolysis18. Increased PDK expression has been detected in many cancers and, therefore, its inhibitor dichloroacetic acid (DCA) has been studied as a possible anti-cancer treatment19,20. To investigate whether PDK expression is increased in the Hs578Ts(i)8cell line variant...
2-deoxy-D-glucose (2-DG), an inhibitor of glycolysis, has been reported to induce starvation and autophagy in cancer cells29. In A549 cells, we observed that TIPRL knockdown significantly augmented the growth-inhibitory effects of 2-DG (Supplementary Fig.S5a). To confirm our results in an...