(2-DG) on M1 macrophages inflamma-tory polarization through glycolysis and mitophagy.Methods: THP-1 cells were divided into three groups: M0group(THP-1 cells were treated by 100 nmol/Lphorbol myristate esterfor 48 h to polarize into M0), M1 group(M0 macrophages wereinduced topolarize into ...
分分类号: R734.2 学校代码:1 0 0 6 2 密密 级: 学 号: 2012601091学位类别: 科学学位□ √ 专业学位 学科门类: 医学 博 士士学位论文 DOCTORAL DISSERTATION 论文题目: 糖酵解抑制剂 2-DG 抑制 ERK 磷酸化的分子机制 T I T L E Molecular mechanism by which the glycolysis inhibitor 2-DG ...
2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity. 体外活性 方法:胰腺癌细胞 MIA PaCa2、BxPC-3、ASPC-1 和卵巢癌细胞 OVCAR-3、HEY、SK-OV-3 用 ...
The strongest increase in ONL cell death was observed after treatment with the glycolysis inhibitor 2-DG (Fig. In the ONL, only the 2-DG treatment caused a significant reduction of nuclear rows (Fig. Organotypic retinal explant cultures as in vitro alternative for diabetic retinopathy studies Afte...
Hematopoietic stem cells (HSCs) exhibit significant functional and metabolic alterations within the lung cancer microenvironment, contributing to tumor progression and immune evasion by increasing differentiation into myeloid-derived suppressor cells (MD
Cancer cells are often characterized by a high metabolic rate exemplified by an elevated rate of glycolysis. This observation forms the basis for positron emission tomography (PET) using glucose analogues such as 18F-2-deoxy-D-glucose (18FDG) to visualize primary tumors and their metastasis. ...
警告 名字:2-DG featured 描述:Description: 2-DG is an inhibitor of glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. 规格:1g;10g;2g;25g;5g;50g; 理论分析:THEORETICAL ANALYSIS MedKoo Cat#: 526090 Name: 2-DG ...
and LDH were suppressed by 2-DG in the cells expressing low ZBTB7A.RNAi-5-8F cells had the lowest 2-DG-induced lactate production.ZBTB7A directly suppressed the promoter region of GLUT1 to regulate GLUT1 expression.Thus,ZBTB7A controls the 2-DG-induced inhibition of glycolysis by affecting ...
This inhibition was fully reversible up to 48 hours of the culture inoculation if 2-DG was removed from the medium, demonstrating the importance of glucose and glycolysis for tumor growth. The inhibitory effects of 2-DG on the viability of cultured cells when applied alone or in combination ...
E3 ubiquitin ligase UBR5 promotes pancreatic cancer growth and aerobic glycolysis by downregulating FBP1 via destabilization of C/EBPα[J]. Oncogene, 2021, 40(2):262-276. 8. Berko ER, Cho MT, Eng C, et al. De...