分分类号: R734.2 学校代码:1 0 0 6 2 密密 级: 学 号: 2012601091学位类别: 科学学位□ √ 专业学位 学科门类: 医学 博 士士学位论文 DOCTORAL DISSERTATION 论文题目: 糖酵解抑制剂 2-DG 抑制 ERK 磷酸化的分子机制 T I T L E Molecular mechanism by which the glycolysis inhibitor 2-DG ...
2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity. 体外活性 方法:胰腺癌细胞 MIA PaCa2、BxPC-3、ASPC-1 和卵巢癌细胞 OVCAR-3、HEY、SK-OV-3 用 ...
(2-DG) on M1 macrophages inflamma-tory polarization through glycolysis and mitophagy.Methods: THP-1 cells were divided into three groups: M0group(THP-1 cells were treated by 100 nmol/Lphorbol myristate esterfor 48 h to polarize into M0), M1 group(M0 macrophages wereinduced topolarize into ...
用途2-脱氧-D-葡萄糖(2-Deoxy-D-Glucose,2-DG)为天然抗代谢物类抗生素,具有能够抑制病毒感染、酵母发酵、致病菌及肿瘤细胞生长等。 生化和生理学机理2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. ...
The strongest increase in ONL cell death was observed after treatment with the glycolysis inhibitor 2-DG (Fig. In the ONL, only the 2-DG treatment caused a significant reduction of nuclear rows (Fig. Organotypic retinal explant cultures as in vitro alternative for diabetic retinopathy studies Afte...
Hematopoietic stem cells (HSCs) exhibit significant functional and metabolic alterations within the lung cancer microenvironment, contributing to tumor progression and immune evasion by increasing differentiation into myeloid-derived suppressor cells (MD
警告 名字:2-DG featured 描述:Description: 2-DG is an inhibitor of glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. 规格:1g;10g;2g;25g;5g;50g; 理论分析:THEORETICAL ANALYSIS MedKoo Cat#: 526090 Name: 2-DG ...
Cancer cells are often characterized by a high metabolic rate exemplified by an elevated rate of glycolysis. This observation forms the basis for positron emission tomography (PET) using glucose analogues such as 18F-2-deoxy-D-glucose (18FDG) to visualize primary tumors and their metastasis. ...
and LDH were suppressed by 2-DG in the cells expressing low ZBTB7A.RNAi-5-8F cells had the lowest 2-DG-induced lactate production.ZBTB7A directly suppressed the promoter region of GLUT1 to regulate GLUT1 expression.Thus,ZBTB7A controls the 2-DG-induced inhibition of glycolysis by affecting ...
Figure 2. (a,b) Analysis of proliferation under glucose restriction or with the 2-DG glycolysis inhibitor in L929 cells. A total of 1 × 104 cells per well were seeded on 96-well plates. On the following day, the cells were incubated in triplicate with (a) 11 mM glucose or (b) 20...