2-deoxy-D-glucose (2DG), a nonmetabolizable glucose analog that partially inhibits glycolysis, was tested in several acute and chronic seizure models. Acutely, 2DG decreases the frequency of high-K~+-, bicuculline- and 4-aminopyridine-induced in-ter ictal bursts in the CA3 region of ...
2DG is well known as an inducer of ER stress, via inhibition of glycolysis and glycosylation. Treatment of 2DG in chondrocytes considerably induced ER stress in a dose- and time-dependent manner, which was demonstrated by a reduction of glucose regulated protein of 94 kDa (grp94), an ER ...
post-traumatic stress disorder, and other adverse consequences depending on the progression of the initial injury, comprising administering to a TBI victim in need thereof a therapeutically-effective amount of an antiglycolytic compound, particularly 2-deoxyglucose (2-DG) or glycolysis-inhibiting analogs...
2DG is a glucose derivative, with the hydroxyl group at the 2-carbon position replaced by hydrogen so that the phosphorylated 2DG by glucose hexokinase is trapped within the cell and cannot be further metabolized through the subsequent steps of glycolysis. The accumulation of 2DG in the cell ...
近日,南方医科大学基础医学院病理学系周军团队在Nature Communications上,在线发表了题为MYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration的研究论文。 该研究揭示了一种核酸外切酶MYG1(...
Glycolysis 长在癌症房间为精力生产和 anabolism 的生长被看作了主要新陈代谢的过程.尽管如此的一个看法为仍然在诊所被使用的强大的成像工具的发展是有帮助的,线粒体... P Porporato,N Filigheddu,JMBS Pedro,... - 细胞研究:英文版 被引量: 0发表: 2017年 在充满想象的积木世界中建筑与探索《乐高世界》于...
Transmissible gastroenteritis virus induces inflammatory responses via RIG-l/NF-κB/HIF-1α/glycolysis axis in intestinal organoids and in vivo Transmissible gastroenteritis virus (TGEV)-induced enteritis is characterized by watery diarrhea, vomiting, and dehydration, and has high mortality in newb......
[4].Xu K, Yin N, Peng M, et al. Glycolysis Fuels Phosphoinositide 3-Kinase Signaling to Bolster T Cell Immunity[J]. Science, 2021. [5].https://www.mskcc.org/news/sloan-kettering-institute-scientists-solve-100-year-old-mystery-about ...
2DG is well known as an inducer of ER stress, via inhibition of glycolysis and glycosylation. Treatment of 2DG in chondrocytes considerably induced ER stress in a dose- and time-dependent manner, which was demonstrated by a reduction of glucose regulated protein of 94 kDa (grp94), an ER ...
Metabolic re-wiring of glycolysis in neoplasms is described as Warburg effect, it is considered to be a source of ATP. The exploitation of metabolic inhibition of glycolysis in EMT is unreported in mesothelioma studies. Cisplatin (C) & Pemetrexed (P) are chemotherapies for malignant mesothelioma....