该研究以“ Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp3)-H Bromination ”为题发表于 Angewandte Chemie International Edition 期刊上,同时相应成果也申请专利 1,4-二氢吡啶类具有广泛的生物活性,其中最重要的是有效的Ca2+通道拮抗剂。到目前为止,市场上有多...
公开(公告)日: 1987-03-04 发明名称: 1 4-DIHYDROPYRIDINES 发明人: 申请人: 申请日期: 1987-01-29 申请公布日期: 1987-03-04 代理机构: 代理人: 地址: 摘要: 二、法律状态 暂无信息 三、权利要求 暂无信息 登录查看更多 打开APP,查看更多专利的权利要求、说明书更多...
1,4-Dihydropyridines: Effects of Chirality and Conformation on Their Activity About 10 years ago, minor changes in the structure of calcium antagonistic 1,4-dihydropyridines (Fig. 1, item 1) were found to lead to derivatives with diametrically opposed pharmacological effects (Fig. 1). The ...
www.nature.com/scientificreports OPEN Novel 1, 4-dihydropyridines for L-type calcium channel as antagonists for cadmium toxicity received: 30 November 2016 accepted: 20 February 2017 Published: 27 March 2017 Madhu Sudhana Saddala1, Ramesh Kandimalla2, Pradeepkiran Jangampalli Adi1,2, ...
1,4-Dihydropyridines 专利内容由知识产权出版社提供 专利名称:1,4 -Dihydr opyr idine s 发明人:Friedrich Bossert,Horst Meyer,Wulf Vater 申请号:US05/501226 申请日:1974 0828 公开号:US03959296A 公开日:19760525 摘要:Derivatives of 4-substituted phenyl 1,4-dihydropyridine 3,5- dicarboxylic acids ...
CCBs may be classified into 1,4-dihydropyridines and nondihydropyridines. Examples of dihydropyridine CCBs are amlodipine, felodipine, and long-acting nifedipine. Examples of commonly used nondihydropyridines are verapamil and diltiazem. These differ significantly in their selectivity within the cardiovascular...
同时,该中心手性能很好的转化为轴手性。该方法为具有广泛生物学活性的1,4-二氢吡啶的研究与制备奠定了良好的基础。 该研究以“Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp3)-H...
该研究以“Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of 1,4-Dihydropyridines by C(sp3)-H Bromination”为题发表于Angewandte Chemie International Edition期刊上,同时相应成果也申请专利。该研究得到中国科学院青年创新促进会、中国科学院西部之光人才A类、以及四川省科技厅中央引导地方项目(2021...
Heterocyclic compounds, especially imidazoles, 1,4-dihydropyridines and 4H-pyrans have a wide range of biological and pharmacological activities. 本论文的主要工作是,以环境友好的PEG-400为反应介质,不加任何催化剂,完成2,4,5-三取代和1,2,4,5-四取代咪唑类、1,4-二氢吡啶类及4H-吡喃类化合物的合成...
3-Formyl-1,4-dihydropyridines, process for their preparation and their pharmaceutical useThe present invention relates to 3-formyl-1,4-dihydropyridines of the general formula I in which R<1> represents phenyl which is optionally ... STOLTEFUSS JUERGEN DIPL.-ING.,FRANCKOWIAK GERHARD DR.,BOESHAGE...