However, it is increasingly clear that the 1,4-dihydropyridine structure is a pharmacophoric template or "privileged structure" that, when appropriately substituted, can exert potent and selective actions at a diverse set of membrane receptors, including ion channels, G protein-coupled receptors and...
An ab initio study compared the molecular structure of 1,4-dihydropyridines with 4H-pyran, 4H-thiopyran, and 4H-selenopyran and found that while the other derivatives studied were essentially planar, 1,4-dihydropyridine had a torsion angle of 10° <2004JST171>. A theoretical study has ...
Structure - activity relationship study of 1,4 - dihydropyridine derivatives blocking N - type calcium channels.. Takashi Yamamoto,Seiji Niwa,Seiji Ohno,et al. Bioorg.Med.Chem Lett . 2006Yamamoto T, Niwa S, Ohno S, et al. Structure-activity re- lationship study of 1,4-dihydropyridine ...
Cardiovascular selectivity of 1,4-dihydropyridine derivatives, efonidipine (NZ-105), nicardipine and structure related compounds in isolated guinea-pig tis... 1.1. The cardiovascular selectivities of 1,4-dihydropyridine derivatives, efonidipine (NZ-105), nicardipine, 3NZ5NIC (the drug with NZ-105-...
1,4-Dihydropyridines: Effects of Chirality and Conformation on the Calcium Antagonist and Calcium Agonist Activities 4-Aryl-l,4-dihydropyridine-3,5-dicarboxylic diesters of the nifedipine type have become almost indispensable for the treatment of cardiovascular diseases s... S Goldmann,J Stoltefuss -...
Crystal structure1,4-dihydropyridineThe crystal and molecular structures of (A) 3,5-Diacetyl-2,6-dimethyl-4-(3′-nitrophenyl)-1,4-dihydropyridine, (B) 3,5-Dibenzoyl-2,6-dimethyl-4-(3′-nitrophenyl)-1,4-di hydropyridine and (C) 3,5-Dicarbomethoxy-2,6-dimethyl-4-(4′-methylthiophen...
1,4-dihydropyridine 3337-17-51,4-Dihydropyridine (CAS 3337-17-5, C5H7N), is a colorless liquid, widely used in pharmaceutical industry as a precursor for the synthesis of various pharmaceutical compounds. It possesses a unique chemical structure and exhibits excellent reactivity, making it a ...
pharmaceutics Article Use of Pluronic Surfactants in Gel Formulations of Photosensitive 1,4-Dihydropyridine Derivatives: A Potential Approach in the Treatment of Neuropathic Pain Giuseppina Ioele 1,*, Rita Muzzalupo 1, Miyase Gözde Gündüz 2 , Michele De Luca 1 , Elisabetta Mazzotta 1, Fedora ...
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate structure CAS No. 1149-23-1 Chemical Name: Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Synonyms diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;DILUDINE;hantzschester;ethidine;1,4-DIHYDRO-2,6-DIMETHYL-3,5...
diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 物化属性我要纠错 密度:1.104熔点:176-183℃沸点:351.8 oC at 760 mmHg折射率:1.489闪光点:351.8 oC at 760 mmHg蒸汽压:4.01E-05mmHg at 25°CPSA:64.63000logP:1.98270溶解度:Soluble in organic solvents.最大Λ:374(EtOH)nm外观:white power存储...