1,4 Dihydropyridine derivatives of the formula:- wherein R is aryl heteroaryl; R' and R are each independently C-C alkyl or 2-methoxyethyl; Y is -(CH)- -CHCH(CH)- or -CHC(CH)-; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may...
1,4 Dihydropyridine derivatives of the formula:- wherein R is aryl heteroaryl; R' and R are each independently C-C alkyl or 2-methoxyethyl; Y is -(CH)- -CHCH(CH)- or -CHC(CH)-; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may...
In the reaction between hexa-2,4-diene and acrolein two stereoisomers may be formed – endo and exo. The endo product is favoured, but how can we tell which one this is? The easiest way to work this out is by drawing the reactants coming together in 3D. J. Sauer, Angew. Chemie ...
1.A compound represented by the following structural formula:or optical isomers, diastereomers, or pharmaceutically acceptable salts thereof wherein:X is —NH—C(O)—;m is 0;j is 1;P1is a substituted or unsubstituted aliphatic, substituted or unsubstituted aralkyl, substituted or unsubstituted h...
The ryanodine receptor (RyR)1 in striated muscles is a high conductance Ca2+ release channel (CRC) located in the terminal cisternae of sarcoplasmic reticulum (SR) (1, 2, 3, 4, 5). In skeletal muscle, activation of the dihydropyridine receptor/voltage sensor by membrane depolarization induces...
1,4 Dihydropyridine derivatives of the formula:- wherein R is aryl heteroaryl; R' and R are each independently C-C alkyl or 2-methoxyethyl; Y is -(CH)- -CHCH(CH)- or -CHC(CH)-; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may...
1,4 Dihydropyridine derivatives of the formula:-\nwherein R is aryl heteroaryl; R' and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; Y is -(CH2)n- -CH2CH(CH3)- or -CH2C(CH3)2-; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ...
Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines. Org. Lett. 2023, 25, 400–404. [Google Scholar] [CrossRef] Yokoe, H.; Kiriyama, A.; Shimoda, M.; Nakajima, S.; Hashizume, Y.; Endo, Y.; Iwamoto, R.; Tsubuki, M.; Kanoh, N. Cis-...
An efficient One pot Synthesis of 1, 4-Dihydropyridine Derivatives under Solvent free ConditionSynthesis of 1, 4 - Dihydropyridines were accomplished by the condensation of Acetoacetnilide, Aromatic aldehydes and Ammonium acetate in the presence of Bismuth trichloride as catalyst under solvent free ...