1,4 Dihydropyridine derivatives of the formula:- wherein R is aryl heteroaryl; R' and R are each independently C-C alkyl or 2-methoxyethyl; Y is -(CH)- -CHCH(CH)- or -CHC(CH)-; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may...
1,4-Dihydropyiridine derivative, a process for preparing the same, a pharmaceutical composition as well as the use thereof. A novel 1,4-dihydropyridine derivative is disclosed having the formula: This derivative and pharmacologically acceptable salts thereof are effective for the treatment and ...
Starting with Toluene, propose an efficient multi step synthesis for 1-(4-(hydroxymethyl)phenyl)ethan-1-ol. (You may need to use protecting groups.) Who discovered one of the first antibiotic: penicillin? The 1,4-dihydropyridine ring is ...
The 1,4-dihydropyridine ring is present in many biologically important molecules and, although technically not a pharmacophore, it is defined as a privileged structure. Explain the meaning of these tw Why does a cell need so many different kinds of enzymes? Wh...
In the reaction between hexa-2,4-diene and acrolein two stereoisomers may be formed –endoandexo. Theendoproduct is favoured, but how can we tell which one this is? The easiest way to work this out is by drawing the reactants coming together in 3D. ...
1,4 Dihydropyridine derivatives of the formula:- wherein R is aryl heteroaryl; R' and R are each independently C-C alkyl or 2-methoxyethyl; Y is -(CH)- -CHCH(CH)- or -CHC(CH)-; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ring which may...
1,4 Dihydropyridine derivatives of the formula:-\nwherein R is aryl heteroaryl; R' and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; Y is -(CH2)n- -CH2CH(CH3)- or -CH2C(CH3)2-; n is 1 to 3; and X is a 5 or 6 membered nitrogen containing aromatic heterocyclic ...
Synthesis and properties of some dihydropyridine and dihydroisoquinoline derivatives of benzylpenicillin. J. Med. Chem. 1989, 32, 1774–1781. [Google Scholar] [CrossRef] [PubMed] Case, D.A.; Babin, V.; Berryman, J.T.; Betz, R.M.; Cai, Q.; Cerutti, D.S.; Cheatham, T.E.; ...
An efficient One pot Synthesis of 1, 4-Dihydropyridine Derivatives under Solvent free ConditionSynthesis of 1, 4 - Dihydropyridines were accomplished by the condensation of Acetoacetnilide, Aromatic aldehydes and Ammonium acetate in the presence of Bismuth trichloride as catalyst under solvent free ...