The present invention relates in certain situations known by the general formula (I) 1-alkyl-3,5-diacyl-1,4 new applications dihydropyridines, processes for their preparation and their use as drugs, as selective potassium channel modulators, in particular application in the treatment of central ...
United States Patent US5646166 Note: If you have problems viewing the PDF, please make sure you have the latest version of Adobe Acrobat. Back to full textHome Search Services Contact us © 2004-2024 FreePatentsOnline.com. All rights reserved. Privacy Policy & Terms of Use....
ChemInform Abstract: 1‐ACYL‐4‐BENZYLIDENE‐1,4‐DIHYDROPYRIDINES; IV. REACTIONS WITH ALDEHYDES AND KETONES TO 1‐PHENYL‐1‐(4‐PYRIDYL)‐2‐ALKANOLSdoi:10.1002/chin.197915258pyridine derivativesE. ANDERSW. WILLJohn Wiley & Sons, LtdChemischer Informationsdienst...
Molecular dockingInhAMTT assayBackground: Tuberculosis remains one of the most deadly infectious diseases worldwide due to the emergence of multi-drug resistance (MDR) and extensively drug resistance (XDR) strains of Mycobacterium tuberculosis (MTB).Venugopala, Katharigatta N.Deb, Pran KishorePillay...
5-ACYL- 1,4-DIHYDROPYRIDINES FOR CONTROL OF DISORDERS OF CNS WITH MODULATING ACTION ON POTASSIUM CHANNELS, CERTAIN SUCH NOVEL COMPOUNDS AND THEIR PREPARATIONPharmaceutical compositions for the treatment of the central nervous system, containing at least one compound of the formula in which R1 ...
Acyl-1,4-dihydropyridines, activated by photochemical, thermal or electrochemical methods, have been successfully applied as radical sources in multiple diverse organic transformations such as acyl radical addition to olefins, alkynes, imines and other acceptors, as well as in the late-stage functional...
The process capitalizes upon the excited‐state reactivity of 4‐acyl‐1,4‐dihydropyridines that, upon visible‐light absorption, can trigger the generation of acyl radicals. By means of a chiral amine catalyst, iminium ion activation of enals ensures a stereoselective radical trap. We also ...
The use of 1-alkyl-3,5-diacyl-2,6-dimethyl-6-aryl-1,4-dihydropyridines of formula (I) is claimed in the prepn. of selective potassium channel modulating medicaments for treating CNS disorders. R1 = 6-10C aryl (opt. substd. by 1-5 of NO2, CN, halogen, CF3 and 1-6C alkylthio)...
The use of 1-alkyl-3,5-diacyl-2,6-dimethyl-6-aryl-1,4-dihydropyridines of formula (I) is claimed in the prepn. of selective potassium channel modulating medicaments for treating CNS disorders. R1 = 6-10C aryl (opt. substd. by 1-5 of NO2, CN, halogen, CF3 and 1-6C alkylthio)...
The present invention relates to the new use of 1-alkyl-3,5- diacyl-1,4- dihydropyridines which are known in some cases, of the general formula (I) ##STR1## in which R.sup.1 to R.sup.4 have the meaning indicated in the description, processes for their preparation and their use ...