For this reason, the clinical utility of nondihydropyridine CCBs is their negative inotropic and chronotropic action on the heart, whereas the vasodilating properties of the dihydropyridines (e.g., amlodipine) make them preferred for the treatment of hypertension. Numerous studies have confirmed that ...
Molecular mode of inhibition of glycogenolysis in rat liver by the dihydropyridine derivative, BAY R3401: inhibition and inactivation of glycogen phosphory... The racemic prodrug BAY R3401 suppresses hepatic glycogenolysis. BAY W1807, the active metabolite of BAY R3401, inhibits muscle glycogen ...
or two groups selected from oxygen, sulphur, imino, substituted imino, phenylene, substituted phenylene, pyridylene, cycloalkylene, 1,4-piperazinediyl, 1-4-piperidinediyl and amido groups, or an acid-addition salt thereof; processes for their manufacture and pharmaceutical compositions containing them...
(redirected fromnondihydropyridine calcium antagonist) Thesaurus Medical Encyclopedia a person who opposes another, often in a hostile manner:The man was his antagonist in a duel.; an enemy, foe; the adversary of the hero or protagonist in a literary work ...
but not the non-dihydropyridine compounds verapamil or diltiazem, dose dependently reduced immobility. Various antidepressant drugs (imipramine, mianserin, citalopram, (+)oxaprotiline) and (-)oxaprotiline in combination with nifedipine facilitated its effect.关键词: Despair test Calcium channel ...
From Houttuynia cordata, a Chinese herbal medicine, pyridine derived alkaloids have been isolated and structurally elucidated as: 3-Decanoyl-6-nonyl-pyridine (1), 3,5-didecanoyl-pyridine (2), three novel 1,4-dihydropyridines: 3,5-didecanoyl-4-nonyl-1,4-dihydropyridine (3), 3-decanoyl-4-...
Recent evidence indicates that Ca2+ dysregulation is involved in the pathogenesis of isoproterenol (ISP)-induced biochemical toxicity and associated oxidative stress. In this study, we investigated the chemopreventive benefit of M3, a 1,4-dihydropyridine calcium channel blocker, against ISP-induced toxici...
Compounds of formula (I) wherein Ar represents a phenyl group having at least one substituent selected from nitro groups, C1-C4, C1-C4 haloalkoxy and cyano AND ATOMS halogens; R represents an alkyl C1-C16, a C3-C6, C1-C4, HAVING SUBSTITUTE C3-C6 alkenyl group C2-C4, a group cinnamyl...
Numerous studies suggest that the dihydropyridine calcium antagonists (DCAs) and nondihydropyridine calcium antagonists (NDCAs) have differential antiprote... GL Bakris,MR Weir,M Secic,... - 《Kidney International》 被引量: 488发表: 2004年 Use of Calcium Channel Blockers and Parkinson's Disease...
The dihydropyridine Dexniguldipine (B859-35) has been shown to inhibit calmodulin and protein kinase C in vitro, and has a significant therapeutic effect on induced neuroendocrine lung tumours in hamsters. As phase I clinical trials with this agent resulted in the development of stable disease in...