Taira N. Differences between dihydropyridine and nondihydropyridine calcium antagonists in inotropic, chronotropic, dromotropic and vascular effects: Differences in underlying mechanism. In: Fleckenstein A, Van Breeman C, Groß R, Hoffmeister F, eds. Cardiovascular Effects of Dihydropyridine-Type ...
Dihydropyridine and nondihydropyridine CCBs have somewhat different side-effect profiles. With dihydropyridines, vasodilation-dependent adverse effects (flushing, palpitations, ankle edema) predominate, whereas with verapamil and diltiazem, vasodilation symptoms are generally milder and cardiac conductance and gast...
For this reason, the clinical utility of nondihydropyridine CCBs is their negative inotropic and chronotropic action on the heart, whereas the vasodilating properties of the dihydropyridines (e.g., amlodipine) make them preferred for the treatment of hypertension. Numerous studies have confirmed that ...
In this study, the fiber type specificity of dihydropyridine receptors (DHPRs) and ryanodine receptors (RyRs) in different rat limb muscles was investigated. Western blot and histochemical analyses provided for the first time evidence that the expression of both receptors correlates to a specific myos...
BACKGROUND: Neural crest-associated congenital heart defects in humans are among the most lethal and costly to treat. In avian and mouse embryos with persistent truncus arteriosus (PTA), the most severe of the neural crest anomalies, there is poor cardiac function because of impaired excitation-co...
(redirected fromnondihydropyridine calcium antagonist) Thesaurus Medical Encyclopedia a person who opposes another, often in a hostile manner:The man was his antagonist in a duel.; an enemy, foe; the adversary of the hero or protagonist in a literary work ...
From Houttuynia cordata, a Chinese herbal medicine, pyridine derived alkaloids have been isolated and structurally elucidated as: 3-Decanoyl-6-nonyl-pyridine (1), 3,5-didecanoyl-pyridine (2), three novel 1,4-dihydropyridines: 3,5-didecanoyl-4-nonyl-1,4-dihydropyridine (3), 3-decanoyl-4-...
The dihydropyridine Dexniguldipine (B859-35) has been shown to inhibit calmodulin and protein kinase C in vitro, and has a significant therapeutic effect on induced neuroendocrine lung tumours in hamsters. As phase I clinical trials with this agent resulted in the development of stable disease in...
The dihydropyridine niguldipine modulates calcium and potassium currents in vascular smooth muscle cells 喜欢 0 阅读量: 7 作者:U. Klöckner,G. Isenberg 摘要: Find more content: like this article Find more content written by:U. KlöcknerG. IsenbergAll Authors ABOUT USHELPCONTACT USAGENTS...
Dihydropyridine derivatives of the formula <IMAGE> I wherein the symbols A, R and R1, R2, R3, R4, R5, R6 and R7 are as described herein. Compounds of formula I have a pronounced calcium-antagonistic activity and can accordingly be used as medicaments, especially for the control or preventi...