(2013) Hantzsch 1,4- dihydropyridine synthesis in aqueous ethanol by visible light. Tetrahedron Letters, 54 (1) 58-62.Ghosh, S., Saikh, F., Das, J. and Pramanik, A.K. (2013) Hantzsch 1,4-Dihydropyridine Synthesis in Aqueous Ethanol by Visible Light. Tetrahedron Letters, 54, 58-62....
Synthesis of 1,4-dihydropyridine derivatives under solvent-free and grinding conditions. Synthetic Commun, 2011;41:2152-60.Min Lei,Lei Ma,Lihong Hu.Thiamine Hydrochloride–Catalyzed One-Pot Synthesis of 1,4-Dihydropyridine Derivatives Under Solvent-Free Conditions[J]. Synthetic Communications .2011(13...
9813关键字:1,4-二氢吡啶类衍生物;氮源;乙酸铵;醛类Hansestersynthesisof1,4–dihydropyridinederivativesresearchAbstract:Inthisthesis,weusedthemethodofHanzstchsynthesistosynthesize1,4-dihydropyridinederivatives.Withparaformaldehyde,ethylacetoacetate,ammoniumacetateassubstrateofthemodelsystem,Weinvestigatedthefactorsthat...
obtainedbythisstraightforwardandenvironmentallybenignmethod.Keywordsaldehyde;1,4-dihydropyridine;aromatization;aqueous-phasesynthesis辅酶NADH模型化合物在酶催化还原反应中起着重要的作用,其中有一种非常重要的Hantzsch酯类1,4-二氢吡啶化合物,作为钙离子通道的调节剂,日益受到人们的广泛注意,在生物和制药学上得到了广泛的...
1,4-Dihydropyridines: Effects of Chirality and Conformation on the Calcium Antagonist and Calcium Agonist Activities 4-Aryl-l,4-dihydropyridine-3,5-dicarboxylic diesters of the nifedipine type have become almost indispensable for the treatment of cardiovascular diseases s... S Goldmann,J Stoltefuss -...
1,4-Dihydropyridine (CAS 3337-17-5, C5H7N), is a colorless liquid, widely used in pharmaceutical industry as a precursor for the synthesis of various pharmaceutical compounds. It possesses a unique chemical structure and exhibits excellent reactivity, making it a valuable building block in ...
The most potent compound, ethyl methyl 4-(3-isopropylcarbonyloxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (14c) exhibited antihypertensive activity comparable with the standard drug鈥攏ifedipine.doi:10.1002/ddr.21056Ranju Bansal...
Keywords Hantzsch ester 1,4-dihydropyridine; reductive amination; coumarin; aldehyde; label 还原胺化是有机合成中的重要反应. 醛和酮在适当 NaBH3CN 进行还原胺化时用量要超过 5 倍甚至更多, 还原剂作用下与伯胺或仲胺制备仲或叔胺[1]. 根据反应 后处理往往产生少量剧毒的HCN 和NaCN 副产物[2]. 而 步骤...
30838毕业论文关键字:1,4-二氢吡啶类化合物、Hantzsch反应、离子液体、一步合成法ThePreparationof1,4-DiludineAbstract:AccordingtoHantzschreaction,weuseionicliquidascatalystpreparingninekindsof1,4-dihydropyridinederivativesbyonestep,obtainedabetterexperimentalcondition:theconsumptionofionicliquidis7.3%(relativeaceto...
Optically-resolved compounds and salts of formula 1 are prepared by following the method of the invention. An unresolved compound of formula 1 is first obtained using methods known in the art. For example, one may use the Hantzsch Dihydropyridine synthesis, using reactants selected to provide the...