MSI-H(MicroSatellite Instability-High,高频微卫星不稳定性)/dMMR(MisMatch Repair-deficient,错配修复蛋白缺失)已经成为胃癌精准治疗的重要靶点之一,相关靶向药物/免疫治疗药物的干预可有效改善这部分标志物阳性患者的预后。 本文基于近期胃癌相关靶向药物/免疫药物的临床研究,...
Results:Of 592 patients, 40 (6.8%) had MSI-high (MSI-H) tumors. Among 582 patients available for immunohistochemistry evaluation, PD-L1 was positive in tumor cells (tPD-L1) of 16 patients (2.7%) and stromalimmune cells(sPD-L1) of 165 patients (28.4%). Multivariable analysis of disease-...
微卫星不稳定性(MSI)状态可能会影响胃癌辅助化疗的疗效。 In this study, the clinical characteristics of MSI-high (MSI-H) gastric cancer and the predictive value of MSI-H for adjuvant chemotherapy in large cohorts of gastric cancer...
参考文献 Zhang Z, Huang J, Li Y, Yan H, Xie J, Wang J, Zhao B. Global burden, risk factors, clinicopathological characteristics, molecular biomarkers and outcomes of microsatellite instability-high gastric cancer. Aging (Albany NY). 2024 Jan 12;15. doi: 10.18632/aging.205431. Epub ahead ...
[2] Lenz H-J, Lonardi S, Zagonel V, et al. Nivolumab plus low-dose ipilimumab as first-line therapy in microsatellite instability-high/DNA mismatch repair deficient metastatic colorectal cancer: Clinical update[J]. Journal of Clinical Oncology, 2020, 38(4_suppl): 11. ...
Liu L, Woo Y, D'Apuzzo M, Melstrom L, Raoof M, Liang Y, Afkhami M, Hamilton SR, Chao J. Immunotherapy-Based Neoadjuvant Treatment of Advanced Microsatellite Instability-High Gastric Cancer: A Case Series. J Natl Compr Canc Netw. 2022 Aug;20(8):857-865. doi: 10.6004/jnccn.2022.7023...
[1]Li J, Deng Y, Zhang W, etal. Subcutaneous envafolimab monotherapy in patients with advanced defective mismatch repair/microsatellite instability high solid tumors[J]. J Hematol Oncol. 2021,14(1):95. *此文仅用于向医学人士提供科学信息,不代表本平台观点...
[6]Kwon M, An M, Klempner SJ, et al. Determinants of Response and Intrinsic Resistance to PD-1 Blockade in Microsatellite Instability-High Gastric Cancer.CancerDiscov.2021;11(9):2168-2185.doi:10.1158/2159-8290.CD-21-0219
[10] Tumour mutational burden as a biomarker in patients with mismatch repair deficient/microsatellite instability-high metastatic colorectal cancer treated with immune checkpoint inhibitors. European Journal of Cancer. 2023 Mar 31. 审校:Faline
2015年首次发现高度微卫星不稳定(microsatellite instable-high,MSI-H)/错配修复缺陷(mismatch repair deficiency,dMMR)型结直肠癌对免疫治疗敏感,开启了结直肠癌的免... 马盛哲 - 《肿瘤》 被引量: 0发表: 2023年 微卫星状态对结肠癌术后辅助化疗决策的影响 (MSI-H)或错配修复蛋白缺乏(dMMR)的结肠癌患者具...