MSI-H(MicroSatellite Instability-High,高频微卫星不稳定性)/dMMR(MisMatch Repair-deficient,错配修复蛋白缺失)已经成为胃癌精准治疗的重要靶点之一,相关靶向药物/免疫治疗药物的干预可有效改善这部分标志物阳性患者的预后。 本文基于近期胃癌相关靶向药物/免疫药物的临床研究,求臻医学将系统性梳理 MS
Complete and rapid response with the combination of immunotherapy and chemotherapy in a young adult patient with microsatellite instability-high metastatic gastric cancer. Journal of Cancer Research and Therapeutics 20(3):p 1045-1048, Apr–Jun 2024. | DOI: 10.4103/jcrt.jcrt_2040_22...
1.JosephChao,MD;CharlesS.Fuchs,MD;KoheiShitara,MD. Assessment of Pembrolizumab Therapy for the Treatment of Microsatellite Instability–High Gastric or Gastroesophageal Junction Cancer Among Patients in the KEYNOTE-059,KEYNOTE-061...
参考文献: [1] Ooki A, et al. Potent therapeutic strategy in gastric cancer with microsatellite instability-high and/or deficient mismatch repair. Gastric Cancer. 2024 Sep;27(5):907-931. doi: 10.1007/s10120-024-0...
Results: Of 592 patients, 40 (6.8%) had MSI-high (MSI-H) tumors. Among 582 patients available for immunohistochemistry evaluation, PD-L1 was positive in tumor cells (tPD-L1) of 16 patients (2.7%) and stromal immune cells (sPD-L1) of 165 patients (28.4%). Multivariable analysis of dise...
Wang X, Zhang Y, Fan G, Wu H, Qi X, Cui X, Zhou C. Case Report: A case of synchronous multiple early gastric cancer with a microsatellite instability-high phenotype. Front Oncol. 2025 Apr 3;15:1527495. doi: 10.3389/fonc.2025.1527495. PMID: 40248200; PMCID: PMC12003148....
[4]Chao J, Fuchs CS, Shitara K, Tabernero J, Muro K,et,al. Assessment of Pembrolizumab Therapy for the Treatment of Microsatellite Instability-High Gastric or Gastroesophageal Junction Cancer Among Patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Clinical Trials. JAMA Oncol. 2021 ...
Zhang Z, Huang J, Li Y, Yan H, Xie J, Wang J, Zhao B. Global burden, risk factors, clinicopathological characteristics, molecular biomarkers and outcomes of microsatellite instability-high gastric cancer. Aging (Albany NY). 2024 Jan 12;15. doi: 10.18632/aging.205431. Epub ahead of print...
2. Assessment of pembrolizumab therapy for the treatment of microsatellite instability-High gastric or gastroesophageal junction cancer among patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 clinical trials 3. Individual Patient Data Meta-Analysis of the Value of Microsatellite Instability As...
HER2阳性胃癌组织MSI和PD-L1表达及意义 第５７卷㊀第１期２０２１年０２月 青岛大学学报(医学版)J O U R N A LO FQ I N G D A O U N I V E R S I T Y (M E D I C A LS C I E N C E S )V o l ．５７,N o ．１F e b r u a r y ㊀２０２１[收稿日期]２０１９Ｇ...