Alpha-phenyl-tert-butylnitrone (PBN) inhibits NFkappaB activation offering protection against chemically induced diabetes. Free Radic Biol Med 2000; 28: 604-614Ho E,Chen G,Bray TM.Alpha-phenyl-tert-butylnitrone (PBN) inhibits NFkappaB activation offering protection against chemically induced diabetes...
alpha-Phenyl-tert-N-butyl nitrone (PBN), a potent reactive oxygen species (ROS) scavenger, has shown robust neuroprotective properties in several models of acute brain injury, although not previously evaluated in traumatic brain injury (TBI). In this study, we assessed the potential efficacy of ...
transplant (BMT) model, in which administration of anti-CD40 antibody early after BMT results in overproduction of interleukin-12 (IL-12) and interferon-gamma (IFN-gamma), and lethal gut toxicity to examine the protective effect of the spin trap inhibitor, alpha phenyl-tert-butyl nitrone (PBN...
摘要: Compounds derived from α-C-phenyl-N-tert-butylnitrone, a process for the preparation thereof and use thereof for the preparation of medicaments for use in preventing or treating oxidative stress-related diseases.收藏 引用 批量引用 报错 分享 文库来源 其他来源 求助全文 NOVEL AMPHIPHILIC ...
伪-phenyl-tert-butyl-nitrone (PBN) a spin adduct forming agent is believed to have a protective action in ischemia-reperfusion injury of brain by forming adducts of oxygen free radicals including 卤OH radical. Electron paramagnetic resonance (EPR) has been used to both detect and monitor the ...
Gendelman, M,Halligan, N,Komorowski, R,Logan, B,Murphy,W.J,Blazar,B.R,Pritchard, K.A,Drobyski, W.R.Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethalcytokine syndrome occurring after agonistic CD40 antibody administration. Blood . 2005...
It has previously been suggested that the spin trap agent 伪-phenyl-N-tert-butylnitrone (PBN) induces neurite outgrowth through activation of the Ras-ERK pathway in PC12 cells. However, the chemical properties of PBN contributing to its biological function and the detailed mechanism for the ...
occlusion in pregnant rats at 20 days gestation has previously been found to cause partial recovery and secondary deterioration of the cellular bioenergetic state in the fetal brain, the subsequent damage being ameliorated by a free radical spin trap agent, α-phenyl-N-tert-butylnitrone (PBN). Ou...
Rogoza,RM,Fairfax,DF,Henry,P.Electron spin resonance spectroscopy reveals alphaphenylNtertbutylnitrone spintraps free radicals in rat striatum and prevents haloperidolinduced vacuous chewing movements in the rat model of human tardive dyskinesia. Synapse . 2004...
Hirano H,,Tabuchi Y,Kondo T,Zhao QL,Ogawa R,Cui ZG,Feril LB,and Kanayama S.Analysis of gene expression in apoptosis of human lymphoma U937 cells induced by heat shock and the effects of α-phenyl N-tert-butyinitrone (PBN)and its derivatives.Apoptosis. 2005...