This chapter describes the spin-trapping agent 伪-phenyl N-tert-butylnitrone (PBN) that offers protection by trapping free radicals during ischemia-reperfusion-mediated injury to the heart and brain of experimental animals. Thus, it has been of considerable interest to establish whether it also ...
英文别名PBN | Phenyl-N-tert-butylnitrone | F0001-0991 | 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide, (N(Z))- | N-tert-Butyl-.alpha.-phenylnitrone | (Z)-N-Benzylidene-2-methylpropan-2-amine oxide | n-tert-butyl phenyl nitrone | (Z)-benzylidene(tert-butyl ...
alpha-Phenyl-tert-N-butyl nitrone (PBN), a potent reactive oxygen species (ROS) scavenger, has shown robust neuroprotective properties in several models of acute brain injury, although not previously evaluated in traumatic brain injury (TBI). In this study, we assessed the potential efficacy of ...
W. A. Bourne : HPLC procedure for the pharmacokinetic study of the spin-trapping agent, α-phenyl- N -tert-butyl nitrone (PBN) . Free Radic. Biol. Med. 1990 , 9 , 93 – 98 .Chen G, Griffin M, Poyer JL, and McCay PB (1990) HPLC procedure for the pharmacokinetic study of the ...
Donepezil, tacrine and alpha-phenyl-n- tert-butyl nitrone (PBN) inhibit choline transport by conditionally immor- talized rat brain capillary endothelial cell lines (TR-BBB). Arch Pharma- col Res (Seoul) 28: 443- 450, 2005.Kang YS, Lee KE, Lee NY, et al. Donepezil, tacrine and alpha...
V. alpha-Phenyl-N-tert-butyl nitrone attenuates methamphetamine-induced depletion of striatal dopam- ine without altering hyperthermia. Synapse 1996; 24: 173-81.Cappon GD, Broening HW, Pu C, Morford L and Vorhees CV (1996) alpha-Phenyl- N-tert-butyl nitrone attenuates methamphetamine-induced ...
Alpha(alpha)-Phenyl-N-tert-butylnitrone (PBN) is an antioxidant used to combat oxidative stress and measure increases in PBN spin-adduct activity. Thus, the aim of this study was to investigate whether VCMs are related to upregulation of DA-D2 receptors or to increased levels of free ...
It has previously been suggested that the spin trap agent 伪-phenyl-N-tert-butylnitrone (PBN) induces neurite outgrowth through activation of the Ras-ERK pathway in PC12 cells. However, the chemical properties of PBN contributing to its biological function and the detailed mechanism for the ...
(1995) The spin-trap N-tert-alpha-phenyl- butylnitrone prolongs the life span o f the senescence accelerated mouse. Biochem Biophys Res Commun 211, 847-849.Edamatsu R, A Mori & L Packer: The spin-trap N- tert-alpha-phenyl-butylnitrone prolongs the life span ...
Peterson SL,Purvis RS,Griffith JW.Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus. Neurotoxicology . 2005...