Phenyl-N-tert- butylnitrone demonstrates broad-spectrum inhibition of apoptosis-associated gene expression in endotoxin-treated rats. Arch Biochem Biophys. 1999; 365:71-4. [PubMed: 10222040]Stewart, C.A., Hyam, K., Wallis, G., Sang, H., Robinson, K.A., Floyd, R.A., Kotake, Y., ...
别名N-叔丁基苯硝酮 英文别名PBN | Phenyl-N-tert-butylnitrone | F0001-0991 | 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide, (N(Z))- | N-tert-Butyl-.alpha.-phenylnitrone | (Z)-N-Benzylidene-2-methylpropan-2-amine oxide | n-tert-butyl phenyl nitrone | (Z)-benzylidene(ter...
beta-amyloidcytotoxicityphenyl N-tert-butyl nitronevasoactivityThis study replicated and extended the previous investigation of conversational turn-taking in ... Ferguson,Alison - 《Aphasiology》 被引量: 44发表: 1998年 Vascular Disease and Vascular Risk Factors and Dementia beta-amyloidcytotoxicityphenyl ...
Phenyl N-tert-butylnitrone (PBN) is the parent of a family of nitrones used as spin-trapping agents to trap free radicals. PBN's pharmacological effects in animal models are extensive, ranging from protection against death after endotoxin shock, protection from ischemia-reperfusion injury, to inc...
PP46 Phenyl n-tert-butylnitrone (PBN), a non-toxic trap of free radicals, inhibits pro-inflammatory cytokinemediated activation of JNK/SAPK and apoptosis in human osteoarthritis chondrocytes Author links open overlay panelShow more Add to Mendeley Share Cite https://doi.org/10.1016/S1063-4584(...
The spin trapping agent phenyl-N-tert-butylnitrone (PBN) was used in vivo to directly assess the formation of ROS during DFP (1.75 mg/kg, s.c.) induced muscle hyperactivity. Pretreatment with PBN (300 mg/kg, i.p.), the concentration necessary for in vivo spin trapping, prevented muscle...
alpha-Phenyl-tert-N-butyl nitrone (PBN), a potent reactive oxygen species (ROS) scavenger, has shown robust neuroprotective properties in several models of acute brain injury, although not previously evaluated in traumatic brain injury (TBI). In this study, we assessed the potential efficacy of ...
Spin trapping agent phenyl N‐tert‐butylnitrone protects against the onset of drug‐induced insulin‐dependent diabetes mellitus 来自 Semantic Scholar 喜欢 0 阅读量: 3 作者:T Tabatabaie,Y Kotake,G Wallis,JM Jacob,R Floyd DOI: 10.1016/S0014-5793(97)00327-X 年份: 1997 ...
Other preferred spin-trapping agents include 5,5-dimethyl pyrroline N-oxide (DMPO), 伪-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN), and (TEMPO) and spin-trapping derivatives thereof. Examples of derivatives of PBN include halogenated derivatives, bifunctional derivatives, conjugates with drugs...
The results show that α-phenyl N-tert-butylnitrone does not only prevent, but it even significantly enhances effects of heparin on the enzyme. This is due to the unique property of α-phenyl N-tert-butylnitrone, independently of spin-trapping capacity, to modify the trypsin structure by ...