Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated lung injury via inhibiting inflammation and apoptosis. Pancreatology. 2016;5:733-738.Liu M, Shi L, Zou X, Zheng X, Zhang F, Ding X, Zhu H, Shen Y: Caspase inhibitor zVAD-fmk protects against acute pancreatitis-associated...
Caspase Inhibitor Z-VAD-FMK 产品规格: 20μL|100μL|5mg 发货周期: 1～3天 产品价格: 询价 本产品仅可用于科研实验,严禁用于其他非科研用途! Z-VAD-FMK是一种可以穿透细胞膜的不可逆的Caspase广普抑制剂,可以抑制由Caspase激活导致的细胞凋亡。Z-VAD-FMK是一种最常用的细胞凋亡抑制剂,常用于观察特定的细胞...
Z-VAD(OMe)-FMK基础信息 产品名：Z-VAD-FMK; pan-caspase inhibitor；泛半胱天冬酶抑制剂 CAS号：187389-52-2 结构式：C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCc1ccccc1 分子式：C22H30FN3O7 分子量 ：467.49 闪点：396.7±32.9 °C 沸点：732....
Upon CD95/Fas ligation, the initiator caspase-8 is known to activate effector caspases leading to apoptosis. In the presence of zVAD-fmk, a broad-spectrum caspase inhibitor, Fas engagement can also trigger an alternative, non-apoptotic caspase-independen
zVAD-fmk (zVAD) is a well- established general caspase inhibitor to block apoptosis. Intriguingly, zVAD is also capable of efficiently inducing necrotic cell death in a selected group of cell types, particularly in L929 cells.19,20 In this study, we first asked whether other caspase inhibitors...
Emerging evidence that Enterovirus A 71(EV-A71)infection closely related to apoptosis.The ZVAD is a caspase inhibitor that can prevent apoptosis.The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral dru...
产品介绍:Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor. 品牌介绍: TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol品牌的客户群分布于40多个国家和地区,已发展成为全球的化合物库和小分子化合物研究供应商。
Z-VAD-FMK是一种细胞渗透性,不可逆的泛caspase抑制剂,能够抑制caspase家族蛋白酶活性和阻断凋亡发生。Jurkat细胞中Z-VAD-FMK抑制Fas诱导的凋亡,胸腺细胞和肝细胞内抑制各种刺激因子激发的凋亡活动。高浓度Z-VAD-FMK (> 100μM)改善TNFα诱导的嗜中性粒细胞凋亡,相反低浓度((1-30 μM)完全阻止TNFα激活的凋亡发...
We also elucidated that this differential efficacy of BocD-fmk and zVAD-fmk resulted from the different effect in inhibiting caspase-6 and that co-treatment of zVAD-fmk and caspase-6 specific inhibitor substantially prevented genistein-induced apoptosis. Our data shows that caspase-6 plays a role...
In this study, we showed that oxygen-glucose deprivation (OGD) combined with a caspase inhibitor zVAD (OGD/zVAD)-induced RIP1 protein expression in a time-dependent manner. We found that geldanamycin (GA), a benzoquinone ansamycin, protected against neuronal injury induced by OGD/zVAD treatment...