Effect of a pan-caspase inhibitor (zVAD-fmk) and a specific caspase-8 inhibitor (zIETD-fmk) on the induction of apoptosis by LBW242 (LBW) or TRAIL or both agents.Eleonora PetrucciLuca PasquiniManuela BernabeiErnestina Saul...
Z-VAD-FMK_Pan-Caspase抑制剂_187389-52-2_Apexbio产品说明书
产品介绍:Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor. 品牌介绍: TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿,致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol品牌的客户群分布于40多个国家和地区,已发展成为全球的化合物库和小分子化合物研究供应商。
is a broad spectrum caspase inhibitor, provides a cost effective, non toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors. [1] it is significantly more effective in preventing apoptosis than the widely used inhibitors, zvad-...
Synergistic induction of apoptosis by AZD8055 and ABT-737 is confirmed on the molecular level, as AZD8055 and ABT-737 cooperate to trigger loss of mitochondrial membrane potential, activation of caspases and caspase-dependent apoptosis that is blocked by the pan-caspase inhibitor zVAD.fmk. Similar...
int j clin exp med. 2009 nov 5;2(4):300-8. biological activity q-vd-oph is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( ic50=25nm), caspase-1 (ic50=50nm), caspase-8 (ic50=100nm) and caspase-9 (ic50=430nm). targets caspase-1 ...
Werthmöller N, Frey B, Wunderlich R, Fietkau R, Gaipl US (2015) Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner. Cell Death Dis 6:e1761. : 10...
One prerequisite that radiotherapy (RT) and chemotherapy (CT) result in anti-tumor immune responses is triggering of immunogenic cell death forms such as necroptosis. The latter is inducible by inhibition of apoptosis with the pan-caspase inhibitor zVAD-
Moreover, ATM/DNA-PKcs inhibitor KU55933, p53 inhibitor PFT-μand pan-caspase inhibitor ZVAD-fmk significantly decreased X-irradiation-induced pan-nuclearγH2AX signals and TUNEL staining, protected HPBLs from apoptosis, but decreased the proliferative response to mitogen in X-irradiated HPBLs. ...