Zonisamide therapy was started at 100 mg/d orally, with gradual increase to 400 mg/d and further increase to 600 mg/d for patients losing less than 5% of body weight at the end of 12 weeks. Placebo dosing was identical. Main Outcome Measure: Change in body weight. Results: Of the 60...
25 mg bd for 7 days, 50 mg bd for 7 days, then increased by 100 mg every 7 days; usual maintenance 300– 500 mg daily, divided into 1 or 2 doses (dose to be increased every 14 days in patients who are not on carbamazepine, phenobarbital, phenytoin, or other potent inducers of cy...
Zonisamide is an antiepileptic drug that demonstrated weight loss efficacy in obese adults (−5.9 vs −0.9 kg) in a 16-week trial with further weight loss in the additional 16-week extension phase.8 In that trial, the daily zonisamide dose was titrated to 400 mg for all patients by ...
Adults >16 years of age: Initially, 100 mg daily.After 2 weeks, may increase dosage to 200 mg daily for at least 2 weeks. May further increase to 300 and 400 mg daily; allow ≥2 weeks between dosage changes (to achieve steady state at each dosage level). Some clinicians may prefer ...
A 42-year-old woman began receiving oral zonisamide [Zonegran] 100 mg/day for the treatment of essential tremor. About 36 hours later, she developed racing thoughts, hyperactivity, insomnia, distractibility and talkativeness. On day 4 of treatment, her husband said that she had not slept in...
Zonisamide is supplied for oral administration as capsules containing 100 mg zonisamide USP. Each capsule contains the labeled amount of zonisamide USP plus the following inactive ingredients: microcrystalline cellulose, hydrogenated vegetable oil, gelatin and colorants. Components of gelatin capsules (For ...
curve reaching linearity after single doses of 100–800 mg and after multiple doses of 100–400 mg daily.1,10 It has a rather long half-life of 60 hours, allowing for once-daily dosing.1,9 The maintenance dosage is 8 mg/kg per day in children and 100–600 mg per day in adults....
25 mg bd for 7 days, 50 mg bd for 7 days, then increased by 100 mg every 7 days; usual maintenance 300– 500 mg daily, divided into 1 or 2 doses (dose to be increased every 14 days in patients who are not on carbamazepine, phenobarbital, phenytoin, or other potent inducers of cy...
Walker, et al. (Fundam Appl. Toxicol.11:333-42 (1988)) disclose that when testing chronic toxicity of zonisamide in beagle dogs, early body weight losses occurred in dogs given 75 mg/kg/day. Morris (Epilepsia41: 39 (2000)) discloses that weight loss was an adverse event for patients ...
20 mg/d 100 6 none 4/f/25 excoriated acne isotretinoin, 30 mg/d 100 3 none 5/f/16 excoriated acne topical 100 8 weight loss 6/f/68 neurotic excoriations and prurigo escitalopram, 10 mg/d 150 10 none 7/m/64 neurotic excoriations and prurigo doxepin, 25 mg/d 100 12 none 8/...