Zonisamide treatment for symptomatic infantile spasms. Neurology 2004; 62: 296–8. Obesity. Anorexia and weight loss have been associated with zonisamide therapy (see Adverse Effects, above) and it has been tried, with some success, as an adjunct in the treatment of obesity1,2 (p.2149); it...
Detecting and Treating Lewy Body Dementia: Misdiagnosis leaves people at risk of serious medication side effects Within the class, the medications with the highest risk were zonisamide, rufinamide, and clorazepate, which had about 70-, 60-, and 56-fold higher odds for SJS and TEN, compared with...
Side effects, such as weight loss, anorexia, drowsiness, tremor, and numbness, occurred in 55.6% of the cases. In most cases, however, treatment could be continued.doi:10.1111/j.1440-1819.1988.tb01366.xShimizu AYamamoto JYamada YTanaka M...
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Adverse Reactions/Side Effects The most ...
It causes cerebellovestibular side effects similar to those of most other AEDs sharing its mechanism of action. In addition, it appears to cause an increased incidence of kidney stones. General Description Zonisamide, a sulfonamide-type anticonvulsant was recentlyapproved for adjunctive therapy in the...
However, the drug has been used in some pediatric patients† [off-label] for the treatment of epilepsy.Studies conducted with pediatric patients indicate that frequency of some adverse effects (e.g., metabolic acidosis, oligohidrosis and hyperthermia) may be increased compared with adults.Oligo...
There is a need for a method to treat an overweight and/or obese subject such that the weight loss is significant and sustained over time. There is also a need for a method to treat eating disorders such as binge-eating disorders, bulimia nervosa and anorexia nervosa. ...
The 62 patients as a group showed significant weight loss in both trials (p values <.001). However, 20 patients (32%) discontinued zonisamide for worsening mood symptoms. Conclusion: Adjunctive zonisamide was associated with beneficial effects on mood and body weight in some patients with bipolar...
Zonisamide for Weight Reduction in Obese Adults: A 1-Year Randomized Controlled Trial BACKGROUND: Obese individuals who have failed to achieve adequate weight loss with lifestyle changes have limited nonsurgical therapeutic options. We evalu... KM Gadde,MF Kopping,WH Nd,... - 《Archives of Inte...
Evaluation of zonisamide for the treatment of focal epilepsy: a review of pharmacokinetics, clinical efficacy and adverse effectsZonisamideclinical efficacyfocal onset seizurespharmacokineticsside effectsIntroduction. Zonisamide is a benzisoxazole with 3-methanesulfonamide side chain, chemically unrelated with ...