weight lossManaging side effects (general information)For healthcare professionals Applies to zonisamide: oral capsule, oral suspension. General adverse events The most common adverse reactions to this drug are somnolence, dizziness, and anorexia.[Ref] ...
Others are weight neutral such as lamotrigine, levetiracetam, and phenytoin or associated with slight weight loss as, e.g., felbamate. The focus of this chapter is on the two AEDs causing strong weight loss: topiramate and zonisamide. For both drugs, several molecular mechanisms of actions are...
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Adverse Reactions/Side Effects The most...
uncontrolled studies suggesting that zonisamide may be effective in the treatment of bipolar disorder did not find confirmation. There is preliminary evidence for possible usefulness of zonisamide in the treatment of obesity and psychotropicassociated weight gain, as well as alcohol dependence and ...
but is well known to have sustained cognitive side effects.28 Additional side effects include weight loss, which may or may not be desirable, and precautions include metabolic acidosis, kidney stones, oligohydrosis, and hyperthermia in pediatric patients, and pregnancy category C in women.2 The ...
Molecular Weight: 212.23 MDL Number: MFCD00865316 MOL File: 68291-97-4.mol Last updated:2025-01-27 09:38:02 Request For Quotation Zonisamide Properties Melting point275°C dec. Boiling point223°C (rough estimate) Density1.4306 (rough estimate) ...
Zonisamide inhibits carbonic anhydrase, and induces weight loss in obese patients. This study explored the relative influence of these two properties, which may both alleviate obstructive sleep apnoea (OSA). Continuous positive airway pressure (CPAP) was used as a standard care comparator. 47 ...
There is a need for a method to treat an overweight and/or obese subject such that the weight loss is significant and sustained over time. There is also a need for a method to treat eating disorders such as binge-eating disorders, bulimia nervosa and anorexia nervosa. ...
Evaluation of zonisamide for the treatment of focal epilepsy: a review of pharmacokinetics, clinical efficacy and adverse effectsZonisamideclinical efficacyfocal onset seizurespharmacokineticsside effectsIntroduction. Zonisamide is a benzisoxazole with 3-methanesulfonamide side chain, chemically unrelated with ...
Conclusions Although only a preliminary study due to strong methodological limitations, and thus requiring confirmation by further controlled investigations, the current results indicate zonisamide may be a potential augmentation option for some depressed patients receiving low doses of duloxetine....