低水平的ZNRD1-AS1表达与不良的临床病理特征、免疫浸润和预后有关。ZNRD1-AS1过表达在体内外均能抑制肺癌细胞的增殖、迁移和血管生成,并抑制裸鼠体内肿瘤生长。 用甲基化抑制剂3-Deazaadenosine或去甲基化抑制剂Meclofenamic处理细胞可以控制ZNRD1-AS1的表达。此外,miR-942/tensin 1(TNS1)轴是ZNRD1-AS1的下游调...
Using in vitro, in vivo, and multi-omics bioinformatics, the present study aims to determine the function and regulatory mechanisms of the long non-coding (lnc)RNA zinc ribbon domain-containing 1-antisense 1 (ZNRD1-AS1). Methods: The RNAs that were bound to the m(6)A 'reader' were ...
Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence both HBV infection and hepatocellular carcinoma development. Mol Carcinog. 2015; 54:1275-1282.Wen J, Liu Y, Liu J, et al. Expression quantitative trait loci in long non- coding RNA ZNRD1-AS1 influence both HBV ...
ZNRD1-AS1, a long noncoding RNA (lncRNA) located in the upstream of ZNRD1, has been reported as an essential component in carcinogenesis. However, the underlying relations of ZNRD1-AS1 with development of EC remain obscure. This study aims to evaluate the potential role of ZNRD1-AS1 ...
Ping-Yu WangJing-Hua LiYue-Mei LiuQing LvNing XieHan-Han ZhangShu-Yang XieImpact JournalsWang PY, Li JH, Liu YM, Lv Q, Xie N, Zhang HH, Xie SY: Single nucleotide polymorphisms in ZNRD1-AS1 increase cancer risk in an Asian population. Oncotarget 2017;8:10064-10070....