DNA bindingprotein-protein interactionsThe zinc finger domain is a very ubiquitous structural element whose hallmark is the coordination of a zinc atom by several amino acid residues (cysteines and histidines, and occasionally aspartate and glutamate). These structural elements are associated with ...
Zinc‐finger Geneszinc‐fingerDNA‐binding proteinprotein–protein interactionscysteinehistidineZinc-fingers (ZnFs) are small protein domains stabilized by one or more zinc ions. ZnF proteins are abundant in higher eukaryotes, and many contain multiple ZnF domains. Initially thought to be peculiar to ...
Keep Your Fingers Off My DNA: Protein–Protein Interactions Mediated by C2H2 Zinc Finger Domains Cys2-His2 (C2H2) zinc finger domains (ZFs) were originally identified as DNA-binding domains, and uncharacterized domains are typically assumed to function... KJ Brayer,DJ Segal - 《Cell Biochemistry...
It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic ...
finger-like structure that projects from the surface of the protein. The tips of these fingers make direct contact with the major groove of the DNA, alternate fingers binding on opposite sides of the helix. Examples of these types of transcription factors include Sp1, the GATA family, and the...
Surface presentation of protein epitopes using bacteriophage expression systems. Curr. Opin. Biotechnol. 2, 668–673 (1991). Article CAS PubMed Google Scholar Rebar, E. J., Greisman, H. A. & Pabo, C. O. Phage display methods for selecting zinc finger proteins with novel DNA-binding ...
Zinc finger protein 292 生物学信息分析 2006 级本硕 2 班 梁光宇 指导老师:吴炳礼,许丽艳,李恩民 ZNF292,全称 Zinc finger protein 292,包含了 1969 个氨基酸残基,分子量为 218446Da。 细胞内定位是在核内,属于 Krueppel C2H2-type 锌指蛋白家族成员。其氨基酸序列如下: >ZNF292 MKCKAGFNSYAELLTHRKEHQVFRAKCMF...
Rev zinc finger protein DNA bindSugiura, Y
However, the zinc-finger DNA-binding domains of the three Gli proteins are not perfectly conserved (Matise and Joyner, 1999), so it is conceivable that their binding affinities differ, although the functional significance of this has not been carefully evaluated in vivo. In addition, ...
& Seto, M. ( 1999b ) Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern . Immunogenetics , 50 , 106 – 108 .Hosokawa Y, Maeda Y, Seto M. Human Helios, an Ikaros- related zinc finger DNA binding protein: cDNA cloning and tissue...