Zinc Finger Nuclease (ZFN) - Modify human genome precisely and efficientlyPriyanka Chaudhary
Zinc-finger nucleases DSB: DNA double strand breaks NHEJ: Non-homologous end joining TALEN: Transcription activator-like effector nuclease SCID: Severe combined immunodeficiency NKC: Natural killer cells ZDD: Zinc-binding dimerization domain NBR: Nonamer binding region PALS: Periarteriolar ly...
17.4.2Gene editing with programmable nucleases: Zinc finger nuclease The ZFN was the first programmable syntheticnucleaseof its kind. The protein consists of a DNA-binding domain on the N-terminus and a cleavage domain on the C-terminus. The DNA-binding domain contains three to sixzinc finger ...
This Kalorama report, Gene Editing Markets (CRISPR-based, Zinc Finger Nuclease [ZFN], TALEN, Other), provides global Revenues and Forecast for the gene editing market by type of product including consumables, instruments, services, cell-lines, animal model...
摘要:来自Milwaukee的消息,威斯康新医学院、Sangamo Biosciences、Sigma-Aldrich、Open Monoclonal Technology以及INSERM公司联合宣布使用zinc finger nuclease (ZFN)技术成功培育出首只靶基因敲除大鼠。 来自Milwaukee的消息,威斯康新医学院、Sangamo Biosciences、Sigma-Aldrich、Open Monoclonal Technology以及INSERM公司联合宣布使用...
Attenuation of Zinc Finger Nuclease Toxicity by Small- Molecule Regulation of Protein Levels Shondra M. Pruett-Miller 1,2 , David W. Reading 1,2 , Shaina N. Porter 1,2 , Matthew H. Porteus 1,2 * 1Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, ...
Zinc-finger nucleases allow targeted genetic modification at loci chosen by the investigator, but the extent of their off-target activity—which could be toxic to cells—has not been evaluated experimentally on a genome-wide scale. Gabriel et al. documen
Zinc finger nuclease (ZFN)-mediated genome editing to generate isogenic, pluripotent cell lines.Science-Business eXchange4, 862 (2011). https://doi.org/10.1038/scibx.2011.862 Download citation Issue Date04 August 2011 DOIhttps://doi.org/10.1038/scibx.2011.862...
c2h2 型锌指对生物大分子的识别c2h2 zinc-finger - 药学学报.pdf,834 药学学报 Acta Pharmaceutica Sinica 20 13, 48 (6): 834 84 1 C2H2 型锌指对生物大分子的识别 多* ( 中国医学科学院、北京协和医学院药物研究所, 天然药物活性物质与功能国家重点实验室, 北京 100050)
Since ZFP7263 and ZFP7264 are two halves of the same zinc-finger nuclease dimer, the data for the host ZFN is the same in each table. The results of these studies broadly matched the patterns observed in the ELISA studies, in that the ZFNs bearing phage-selected linkers showed both higher...