cerevisiae, plays an essential role in the mating signal pathway. The functional domains of Ste5 comprise a nuclear localization domain, a membrane-binding domain, and kinase-binding region [11]. Ste5 recruits
The mating pathway in yeast Saccharomyces cerevisiae has long been used to reveal new mechanisms of signal transduction. The pathway comprises a pheromone receptor, a heterotrimeric G protein, and intracellular effectors of morphogenesis and transcription. Polarized cell growth, in the direction of a ...
King K, Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ (1990) Control of yeast mating signal transduction by a mammalian β2-adrenergic receptor and Gsα subunit. Science 250:121–123. Article PubMed CAS Google Scholar LaMantia M, Miura T, Tachikawa H, Kaplan HA, Lennarz WJ, Mizuna...
invasion into tissues, and virulence34. InS. cerevisiaehaploid cells, filamentous growth is triggered by growth in a non-preferred carbon source. The response is regulated by multiple signal transduction pathways35,36, including the RAS-cAMP-PKA pathway23,37,38,39and the filamentous growth MAPK pa...
J. (1990) Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. Science 250, 121–123. Article PubMed CAS Google Scholar Brake, A. J. (1990) Alpha-factor leader-directed secretion of heterologous proteins from yeast. Methods Enzymol. ...
Biomarker Target alpha-Mating Factor Research Area Cell Signaling Sub-category Research Area GPCR Signal Transduction Usage Research use Source Source / Species yeast Downloads AS-60221-5 alpha Mating Factor Pheromone yeast (EN) 2/24/2020 | PDF | TDS (Technical Data Sheet) | 132.325...
cerevisiae prepro α mating factor signal sequence for the secretion of recombinant proteins, because of the inefficient cleavage of Ste13 peptidase[27]. It also suggests that translocon machinery and signal peptide peptidase complex of yeast and human cells are compatible, because native signal ...
mating of cells that can divide in itspresence causes an immediate arrest in all stages of the mating pathway.Similar treatment with P. acaciae toxin results in mating cells arresting asprezygotes.INTRODUCTIONProteinaceous toxins produced by the yeasts Kluyveromyces lactis and Pichiaacaciae share ...
Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes Mol. Cell. Biol., 13 (1993), pp. 5659-5669 Correction (1994) Mol. Cell. Biol. 14, 2222 View in ScopusGoogle Scholar 54. Gartner A., Jeoung D.-I., Bourlat S., Cross F....
no agonist-dependent activation of the mating signal transduction pathway could be detected by any of the typical in vivo assays; for example, imposition of G1 arrest, induction of gene expression alteration of morphology (so-called “shmoo” formation) or stimulation of mating. A likely explanati...