However, the role of YAP1-TEAD1-PGC1α signaling in mitochondrial structure, cellular metabolism, and angiogenesis in endothelial cells (ECs) remains unclear. We now find that knockdown of TEAD1 decreases the expression of PGC1α and suppresses mitochondrial biogenesis, glycolysis, and oxygen ...
YAP1/TEAD1 associate with active enhancers.Claudia, SteinAnaïs, Flore BardetGuglielmo, RomaSebastian, BerglingIeuan, ClayAlexandra, RuchtiClaudia, AgarinisTobias, SchmelzleTewis, BouwmeesterDirk, Schübeler
百度爱采购为您找到541条最新的yap1-tead1-glut1轴产品的详细参数、实时报价、行情走势、优质商品批发/供应信息,您还可以免费查询、发布询价信息等。
The Hippo TEAD-transcriptional regulators YAP1 and TAZ are central for cell renewal and cancer growth; however, the specific downstream gene networks involved in their activity are not completely understood. Here we introduce TEADi, a genetically encoded inhibitor of the interaction of YAP1 and TAZ...
本研究的目的是分析牛IFNT蛋白不同亚型的结构差异以及进而导致的功能差异,并研究了TEAD家族及YAP1对IFNT基因表达的调控作用,为完全阐明妊娠识别机制提供理论依据. 本研究通过Prosite数据库比对牛IFNT1和IFNTc1蛋白氨基酸序列,进而研究其蛋白的结构差异,发现IFNTc1蛋白存在着一段酪蛋白激酶2(CK2)序列,而其同源基因IFNT1...
目的探讨核因子κb激酶亚基ε的抑制剂(IKBKE)、Yes相关蛋白1(YAP1)和转录增强结构域转录因子2(TEAD2)在结直肠癌(CRC)组织中的表达及其临床意义。方法收集2016年1月至2017年12月在蚌埠医科大学第一附属医院手术切除的142例CRC组织及对应癌旁组织,采用免疫组化法检测标本中IKBKE、YAP1和TEAD2的表达情况。分析3种蛋...
CIL56(CIL-56, CA3, CA-3)是一种有效的选择性ferroptosis诱导剂,通过增加铁依赖性ROS诱导铁死亡。CIL56还能抑制YAP1/Tead转录活性,对YAP1高表达食管腺癌表现出抗癌活性。此外,CIL56可以通过脂质合成限速酶ACC1触发细胞死亡。 产品性质 英文别名(English Synonym) ...
Because of the emerging role of these proteins as mediators of normal growth and tumorigenesis, we assessed the exogenous modulation of their activity, either by in vitro gene silencing or by pharmacological inhibition of the YAP1/TEAD complexes, both in vitro and in vivo. Moreover, we ...
53548ES 翌圣生物 ≥98% 5 mg 1000 1,105.00 元 53548ES 翌圣生物 ≥98% 25 mg 1000 3,525.00 元 公司信息 产品详情 公司介绍 翌圣生物科技(上海)股份有限公司 联系人:翌圣生物 吴经理 手机:13916346489 联系电话:021-34615975 QQ:3455256316 邮箱:wuchufeng@yeasen.com 网址:https://www.yeasen....
Kaplan-Meier生存分析显示IKBKE、YAP1和TEAD2阳性表达组的总生存率降低。Cox回归分析显示IKBKE、YAP1和TEAD2阳性、肿瘤分化程度高、TNM分期高是CRC患者预后的独立危险因素。结论CRC中IKBKE、YAP1和TEAD2阳性表达与肿瘤的分化程度、TNM分期、转移等因素有关,可能成为CRC治疗的潜在靶点;检测这3个蛋白的表达有助于评估...