YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis. Biomed. Pharmacother. 2017, 95, 789-794. [CrossRef] [PubMed]Lin C, Xu X. YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis. Biomed...
However, the role of YAP1-TEAD1-PGC1α signaling in mitochondrial structure, cellular metabolism, and angiogenesis in endothelial cells (ECs) remains unclear. We now find that knockdown of TEAD1 decreases the expression of PGC1α and suppresses mitochondrial biogenesis, glycolysis, and oxygen ...
YAP1/TEAD1 associate with active enhancers.Claudia, SteinAnaïs, Flore BardetGuglielmo, RomaSebastian, BerglingIeuan, ClayAlexandra, RuchtiClaudia, AgarinisTobias, SchmelzleTewis, BouwmeesterDirk, Schübeler
不同的YAP1融合的YAP活性是耐负Hippo通路调节由于组成型核定位和耐降解的YAP1融合蛋白。这些致癌性YAP1融合的TEAD结合域的遗传破坏足以抑制体内肿瘤的形成,而YAP1-TEAD相互作用的药理学抑制抑制YAP1的融合表达细胞系的生长在体外。这些结果强调了在这些基因融合中发现的TEAD依赖性YAP活性对肿瘤发生至关重要,并暗示这些...
YAP1/TEAD1 of the Hippo pathway, suggesting that it is sensitive to cell contact‑dependent interactions.T h e Hippo pathway regulates diverse biological processes, including cell growth, cell contact, cell fate, organ size, development, and carcinogenesis 1,2 . Th e STK4-encoded MST1 and ...
However, the role of YAP1-TEAD1-PGC1α signaling in mitochondrial structure, cellular metabolism, and angiogenesis in endothelial cells (ECs) remains unclear. We now find that knockdown of TEAD1 decreases the expression of PGC1α and suppresses mitochondrial biogenesis, glycolysis, and oxygen ...
8.yap1或yap1-tead活性的增加并不局限于hippo通路中的遗传改变并且还可以是通过多个相互连接的信号上调的结果。肿瘤发生中起关键作用的许多通路都进入了hippo-yap1/taz/tead1级联,详细描述的例子包括rtk-ras-raf-mek-erk、wnt、tgf-β和ampk通路(综述于han等人,j transl med 2019)。因此,至少部分依赖于yap1-tea...
CIL56(CIL-56, CA3, CA-3)是一种有效的选择性ferroptosis诱导剂,通过增加铁依赖性ROS诱导铁死亡。CIL56还能抑制YAP1/Tead转录活性,对YAP1高表达食管腺癌表现出抗癌活性。此外,CIL56可以通过脂质合成限速酶ACC1触发细胞死亡。 产品性质 英文别名(English Synonym) ...
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目的探讨核因子κb激酶亚基ε的抑制剂(IKBKE)、Yes相关蛋白1(YAP1)和转录增强结构域转录因子2(TEAD2)在结直肠癌(CRC)组织中的表达及其临床意义。方法收集2016年1月至2017年12月在蚌埠医科大学第一附属医院手术切除的142例CRC组织及对应癌旁组织,采用免疫组化法检测标本中IKBKE、YAP1和TEAD2的表达情况。分析3种蛋...