(Th1) cells after ischemic myocardial injury.Hypothesis: Deletion of XCR1+ cDC1 cells after myocardial infarction (MI) might improve adverse cardiac remodeling through the suppression of Th1 cells.Methods: Using Xcr1+/DTRvenus mice, which allow the XCR1-expressing cell elimination by treatment ...
Diphtheria toxin receptorDendritic cells (DCs) are one of the key populations controlling immune responses. To establish a cell depletion system in vivo, human diphtheria toxin (DT) receptor (DTR) is transduced to the mice indoi:10.1007/978-1-4939-3606-9_17Hiroaki Hemmi...
XCR1-venus and XCR1-DTRvenus mice should be useful for elucidating the functions and behavior of XCR1-expressing DCs, including CD8α+ and CD103+ DCs, in lymphoid and peripheral tissues.EBSCO_AspJournal of Immunology
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