将creERT2-WPRE-polyA插入到小鼠Cx3cr1基因起始密码子处。 应用领域:Cre工具鼠,单核吞噬细胞等区域 *使用本品系发表的文献需注明: Cx3cr1-CreERT2 mice (Cat. NO. NM-KI-200157) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 图1 Cx3cr1CreERT2/+; Rosa26tdTomato/+小鼠...
Cx3cr1CreERT2 mice express Cre recombinase in a tamoxifen-inducible manner and have been widely used to delete target genes in microglia, since microglia are long-lived cells and outlive peripheral macrophages, which continuously turn over and lose their gene modification over time. ATG7 is an ...
4 Detection of tdTomato(red) in various tissues of Cx3cr1Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in some cells of the brain, liver, lung, stomach, salivary gland, small intestine, spinal cord, spleen, testis and epididymis, skin and subcutaneous tissue, ...
inducible and transient deletion ofAtg7in the intestinal macrophages in adult mice offers similar phenotypes compared with the continuous deletion ofAtg7during development into adulthood. Based on our result, we suggest to check intestinal or kidney...
To study the role of ATG7 in adult microglia, we generated Cx3cr1CreERT2:Atg7fl/fl mice and deleted Atg7 at the age of 8 weeks, and found induction of intestinal adhesion. Since intestinal adhesion is caused by excessive inflammation, these results suggest that deletion of Atg7 in ...
Therefore, gene deletion in microglia lasts longer than in peripheral monocytes and macrophages; this unique physiological feature of microglia makes Cx3cr1-Cre mice an invaluable tool to express or delete genes of interest in a microglia-specific manner in the CNS [9]. Previously, we reported ...
Cre+ mice also had fewer Retnlahi macrophages than Cre mice both at days 0 and 7 post DSS. Genes highly expressed in the Retnlahi cluster are associated with wound healing and maintenance of vascular integrity indicating their loss could account for the enhanced GI bleeding in the inflamed Cre...
*使用本品系发表的文献需注明: Cx3cr1-2A-tdTomato-IRES-CreERT2 mice (Cat. NO. NM-KI-242749) were purchased from Shanghai Model Organisms Center, Inc.. 相关品系 Cx3cr1-Flox 品系名:C57BL/6Smoc-Cx3cr1em1(flox)Smoc 品系状态:活体 | 目录号:NM-CKO-226496 Cx3cr1-CreERT2 品系名:C57BL...
*使用本品系发表的文献需注明: Cx3cr1-CreERT2 mice (Cat. NO. NM-KI-200157) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 Fig. 1 CreERT2-mediated recombination in the brain of Cx3cr1CreERT2/+; Rosa26tdTomato/+ mouse. Detection of tdTomato (red) in the brain...
*使用本品系发表的文献需注明: Cx3cr1-2A-tdTomato-IRES-CreERT2 mice (Cat. NO. NM-KI-242749) were purchased from Shanghai Model Organisms Center, Inc.. 相关品系 Cx3cr1-Flox 品系名:C57BL/6Smoc-Cx3cr1em1(flox)Smoc 品系状态:活体 | 目录号:NM-CKO-226496 ...