品系描述 利用CRISPR基因编辑技术,将iCre替换小鼠Cx3cr1基因的编码区。 应用领域:Cre工具鼠,单核吞噬细胞系统 *使用本品系发表的文献需注明: Cx3cr1-Cre mice (Cat. NO. NM-KI-200079) were purchased from Shanghai Model Organisms Center, Inc.. ...
人类同源基因 CX3CR1 品系描述 将loxp-Dre-loxp-Wpre-pA插入到小鼠Cx3cr1基因起始密码子处。 *使用本品系发表的文献需注明: Cx3cr1-cDre mice (Cat. NO. NM-KI-230181) were purchased from Shanghai Model Organisms Center, Inc.. 你也可能感兴趣...
Surprisingly, fate mapping data using the newly developed Ms4a3Cre Rosa Stopf/f TdT model indicate that less than 50% of Ccr2+ KRM are derived from Ly6chi monocytes. Instead, we find that Ccr2 expression in KRM reflects their spatial distribution as this cell population is...
Cx3cr1CreERT2 mice express Cre recombinase in a tamoxifen-inducible manner and have been widely used to delete target genes in microglia, since microglia are long-lived cells and outlive peripheral macrophages, which continuously turn over and lose their gene modification over time. ATG7 is an ...
(qRT-PCR) showed that, at 1 week after TAM injection, theAtg7mRNA level was reduced in microglia and intestinal macrophages isolated fromCx3cr1CreERT2:Atg7fl/flmice (Fig.1c; Mann–Whitney test;p <0.05), but not in CD11b+peripheral blood mononuclear cells (PBMCs) or spleen ...
In adult Cx3cr1CreERT2 mice, Cre activity– dependent tamoxifen (TAM)-inducible gene recombin- ation is possible in CX3CR1+ macrophages (microglia, in- testinal, and renal) but not in CX3CR1− macrophages (including peritoneal, splenic, and alveolar) [8]. Microglia are long-lived ...
Cx3cr1CreERT2 mice express Cre recombinase in a tamoxifen-inducible manner and have been widely used to delete target genes in microglia, since microglia are long-lived cells and outlive peripheral macrophages, which continuously turn over and lose their gene modification over time. ATG7 is an ...
When submitted to the tail suspension test 48 and 72 h after LPS, an increased duration of immobility was evident only in CX3CR1-/- mice. This depression-like behavior in CX3CR1-/- mice was associated with a persistent activated microglial phenotype in the hippocampus and prefrontal cortex....
When submitted to the tail suspension test 48 and 72 h after LPS, an increased duration of immobility was evident only in CX3CR1-/- mice. This depression-like behavior in CX3CR1-/- mice was associated with a persistent activated microglial phenotype in the hippocampus and prefrontal cortex....
通过Tfam-Flox(NM-CKO-200173)与Cx3cr1-Cre(NM-KI-200079)小鼠交配获得。 *使用本品系发表的文献需注明: Tfam-Flox/Cx3cr1-Cre mice (Cat. NO. NM-XA-242083) were purchased from Shanghai Model Organisms Center, Inc.. 相关品系 Tfam-Flox ...