X-inactive specific transcript (Xist) long noncoding RNA (lncRNA) is thought to catalyze silencing of X-linked genes in cis during X-chromosome inactivation, which equalizes X-linked gene dosage between male and female mammals. To test the impact of Xist RNA on X-linked gene silencing, we...
Imprinted X-linked genes, |[lsquo]|feminine intuition|[rsquo]| and the public (mis)understanding of science The report of an imprinted locus on the X chromosome influencing social behaviour was taken up with fervour by the media and reported in a way which neglec... J Scourfield,P Mcguffi...
先证者母亲携带Yq12片段,女性特征,具备生育能力,无不良孕产史。 在线人类孟德尔遗传数据库(OMIM Genes数据库,https://omim.org/)显示Xp22.3区包含31个OMIM基因,主要致病基因有矮小同源盒基因(short stature homeobox,SHOX)、芳基硫酸酯酶...
This screen yielded a list of seventeen candidate proteins, some of which are also known to be required for XCI12,23,34,35,67. Given this, we selected this suite of genes to target in our screen. Xmas mESCs were transduced with validated hairpins (Supplementary Fig. 3a) at day 2 of ...
genes from the Developmental Disorders Gene-to-Phenotype list (DDG2P) and Online Mendelian Inheritance in Man (OMIM) (see ‘Methods’) as X-linked dominant only (orange), X-linked recessive only (green) or both/uncertain (blue).P-values for the genes under different tests are shown in ...
Novel genes implicated in non-syndromic and syndromic XLMR The list of genes that have been implicated in non-syndromic and syndromic forms of XLMR continues to grow; at present, it comprises 61 entries (Figure 1; see also Table 1 and Supplementary Table 1). Recent additions include GRIA3,...
Our analyses suggest that the extensive female bias of Tribolium X chromosome gene expression is due to hyperexpression of X-linked genes in both males and females. We propose that the overexpression of X chromosomes in females is an evolutionary side effect of the need to dosage compensate in ...
ubiquitinylation of Klhl13 substrates might lead to consequences other than proteasomal degradation, in which case also Klhl13 interaction partners that were not upregulated in Klhl13 knockout cells might be involved in Klhl13 functions. We have thus narrowed down the list of candidate genes that...
The number of X-linked genes and microRNAs with an identified role in immunity is increasing, and it is possible that naturally occurring variations in these genes and microRNAs account for immunological differences between genders. Abstract
We found 1,098 genes in the sequence, of which 99 encode proteins expressed in testis and in various tumour types. A disproportionately high number of mendelian diseases are documented for the X chromosome. Of this number, 168 have been explained by mutations in 113 X-linked genes, which in...