X-inactive specific transcript (Xist) long noncoding RNA (lncRNA) is thought to catalyze silencing of X-linked genes in cis during X-chromosome inactivation, which equalizes X-linked gene dosage between male and female mammals. To test the impact of Xist RNA on X-linked gene silencing, we...
genes interspersed throughout the remainder of the chromosome that are expressed from both the active and, at varying levels, the inactive chromosomes.2 – 4 Some estimates indicate that 10 – 20% of X-linked genes escape inactivation, with the majority *Correspondence: Professor I Craig, SGDP...
The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites. The DCC localizes to the X chromosomes in hermaphrodites but not in males, and some subunits...
Imprinted X-linked genes, |[lsquo]|feminine intuition|[rsquo]| and the public (mis)understanding of science The report of an imprinted locus on the X chromosome influencing social behaviour was taken up with fervour by the media and reported in a way which neglec... J Scourfield,P Mcguffi...
Our analyses suggest that the extensive female bias of Tribolium X chromosome gene expression is due to hyperexpression of X-linked genes in both males and females. We propose that the overexpression of X chromosomes in females is an evolutionary side effect of the need to dosage compensate in ...
Library Projects 2010 / 2011 Non-Human Farmers Dosage compensation for X-linked genesAnderson, R W
Clustering of cognition genes on the X-chromosome? In their recent compilation of Mendelian disorders that are consistently or occasionally associated with mental retardation, Inlow and Restifo [56•] concluded that the contribution of X-linked genes is significantly higher than would be expected, ...
Recently, genes (RP2 and RPGR) from two X-linked loci have been posi- tionally cloned and mutations have been identified in many families. To further evaluate allelic and non-allelic hetero- geneity and the genotype — phenotype relationships, and to determine the prevalence of mutations in ...
For humans, about 15-30% of the X-linked genes have been reported to undergo the XCI-E [7]. Finally, the XCI-S is defined as more than 75% of the cells in females inactivating the same allele [9]. For some extreme skewed cases, it is possible that more than 90% of the cells...
What is more, it improved the lipid profile and upregulated the gene expression of key beta-cell genes, inter-alia insulin regulatory transcription factors. Thus, ISV could be considered in the prevention of obesity complications. Obesity is a multifactorial metabolic disease characterized by ...