While modeling WW domains for which structures have not been determined we uncovered a case of potential molecular and functional convergence between WW and SH3 domains. The binding surface of the modeled WW domain of Npw38 protein shows a remarkable similarity to the SH3 domain of Sem5 protein...
Also contained within the LMP2A amino terminal domain are five proline-rich regions, three of which possess the PxxP core consensus sequence required for interacting with SH3 domains and two of which possess the PPxY core consensus sequence (PY motif) required for interacting with class I type...
Crystal structure of a src-homology 3 (SH3) domain Nature, 359 (1992), pp. 851-855 View in ScopusGoogle Scholar 13. Yu H., Rosen M.K., Bum Shin T., Seidel-Dugan C., Brugge J.S., Schreiber S.L. Solution structure of the SH3 domain of Src and identification of its ligand-bin...
WW Domain A two-tyrosine motif (38–40 amino acids) of signaling proteins and a binding site for proline-rich peptides. The binding of a WW domain by Pin1 and Nedd4 proteins apparently does not require prolines for binding, rather the WW domains are binding sites for phosphoserine and ph...
The WW domain, also known as WWP, or rsp5 domain, is a ~40 amino acid module which was identified in late 1994 by three different groups (Bork and Sudol 1994; André and Springael 1994; Hofmann and Bucher 1995). The name WW or WWP is based on the primary sequence of the domain, ...
Using a proteomic approach, we discovered potential regulatory proteins that interact with TAZ WW domain and identified Wbp2. The interaction of Wbp2 with TAZ is dependent on the WW domain of TAZ and the PPXY-containing C-terminal region of Wbp2. Knockdown of endogenous Wbp2 suppresses, ...
The β-dystroglycan peptide binds a composite surface formed by the WW domain and one of these EF-hands. Additionally, the structure reveals striking similarities in the mechanisms of proline recognition employed by WW domains and SH3 domains. 展开 ...
We report cDNA cloning and characterization of the human and mouse orthologs of the chicken YAP (Yes-associated protein) gene which encodes a novel protein that binds to the SH3 (Src homology 3) domain of the Yes proto-oncogene product. Sequence comparison between mouse, human, and chicken YA...
The E3 ubiquitin ligase WWP1 (WW Domain-containing E3 Ubiquitin Protein Ligase 1) is a member of the HECT (Homologous to the E6-associated protein Carboxyl Terminus) E3 ligase family. It is conserved across several species and plays crucial roles in vari
Although it is known that Rsp5p binds Mga2p and Spt23p via an imperfect WW domain-binding site (LPKY) that is located within the carboxy-terminal domain of the proteins, it remains unclear which WW domains mediate binding. We show that Rsp5p mutants harboring mutations in single WW domains...