Synonyms src homology 2 (SH2)/ src homology 3 (SH3) domains Definition Proteins containing SH2/SH3 domains play critical roles in regulating the formation of intracellular signal transduction complexes. SH2 and SH3 domains recognize amino acid motifs containing phosphotyrosine and polyproline, ...
Certain SH2 and SH3 domains have been shown to form functional and physical interactions. The structural basis of dimer formation was studied by docking three dimensional structures of the domains and by analysing structural and functional properties of the dimers. The experimentally verified dimers ...
SH2 and SH3 domains are small protein modules of about 100 and 60 amino acids, respectively, that are found in many proteins involved in intracellular signal transduction. SH2 and SH3 domains mediate protein-protein interactions and modulate enzyme activity by their ability to bind to specific ...
1991. The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110. EMBO J.10:1689--98... S B,Kanner,A B,... - 《Embo Journal》 被引量: 311发表: 1991年 A novel signaling molecule, p130, forms stable complexes in vivo with v-...
SH2 and SH3 domains are small protein modules that mediate protein-protein interactions in signal transduction pathways that are activated by protein tyrosine kinases. SH2 domains bind to short phosphotyrosine-containing sequences in growth factor receptors and other phosphoproteins. SH3 domains bind ...
activating protein (GAP)5and selectively binds, directly or indirectly, polyribonucleotides. Because the Src SH3 domain also binds heterogeneous nuclear ribonucleoprotein K, these results raise the intriguing possibility that c-Src may regulate the processing, trafficking or translation of RNA in a ...
The SH2 and SH3 domains of the inactive kinases are seen to be tightly coupled by the connector between them, impeding activation. Dephosphorylation of the tail reduces the coupling between the SH2 and SH3 domains in the simulations, as does replacement of connector residues with glycine. A ...
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SH2 and SH3 domains as targets for anti-proliferative agents Michel Vidal, ... Christiane Garbay, in Critical Reviews in Oncology/Hematology, 2001 1. 1.Introduction 2. SH2 and/or SH3 domain-containing proteins 2.1. SH2 and/or SH3 domain-containing proteins in signaling pathways 2.2. SH2...
We have constructed a series of mutants with deletion, linker insertion, and point mutations in the v-crk oncogene of avian sarcoma virus CT10. The v-crk gene contains no apparent catalytic domain, but does contain two blocks of homology to putative regulatory domains, termed SH2 and SH3, ...