Tumor suppressor gene WT1 in renal diseasesYouxin YANGMarieClaire GUBLER
WT1基因(Wilm tumor gene1)最早发现于1899年, 德国科学家Wilms对肾母细胞瘤进行病例描述,从Wilms瘤(Wilms tumor)细胞中分离出来的一种含锌指状多肽的抑癌基因,之后命名为Wilms Tumor,WTl 基因可以调节细胞的增殖、生长、分化、凋亡。 •WT1的发展: 1.1992 美国科学家Miwa发现血液肿瘤患者WT1基因表达增高。 2.2001 ...
8.Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, et al. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest 2011, 121(5): 1894-1904. 9.Dehbi M, Hiscott J, Pelletier J. Activation of the wt1 Wilms' tumor suppressor gene by NF-kap...
Campbell CE, Kuriyan NP, Rackley RR, Caulfield MJ, Tubbs R, Finke J, Williams BR: Constitutive expression of the Wilms tumor suppressor gene (WT1) in renal cell carcinoma. Int J Cancer 1998, 78:182-188.Campbell et al., " Constitutive Expression of the Wilms Tumor Suppressor Gene (WT1)...
性质:又称Rb基因。是一特定的DNA片段。系首次分离到的抑癌基因(tumor suppressor gene)。正常人都有完整的Rb基因。Rb基因的部分缺失,不但可引起视网膜母细胞瘤,并且还证明诸如结肠癌等可检出Rb基因的缺陷。Rb基因位于13号染色体,有200Kb大小,含有27个外显子,编码928个氨基酸。
摘要:WT1(Wilms tumor suppressor gene 1)是一种肿瘤抑制基因,对泌尿生殖系的发育和Wilms肿瘤的发生发展具有重要的意义。目前研究认为WT1基因突变可引起Denys-Drash综合征(DDS)、Frasier综合征(FS)和WAGR综合征等一些先天性综合征,均以生殖腺发育异常和(或)伴有Wilms肿瘤及肾病为主要特点。其中Denys-Drash综合征和Frasi...
1) Wilm's tumor suppressor(WT1) 肾母细胞肿瘤抑制因子(WT1)2) Wilms tumor 1 gene 肾母细胞瘤抑制基因 1. Objective This paper aims at studying the effects of alphacalcidol (αD 3) on Wilms tumor 1 gene (WT 1) expression of renal tissues and on proteinuria in rats with nephrotic ...
We have studied the ability of the wt1 tumor suppressor gene product to repress different classes of activation domains previously shown to stimulate the initiation and elongation steps of RNA polymerase II transcription in vivo. Repression assays revealed that WT1 represses all three classes of activat...
The article reports on a long-term surveillance of 71 patients with mutations in the suppressor 1 gene of Wilms tumor (WT1) and the protein 尾1 gene associated with cadherin. Results indicated that patients who have the WT1 gene mutations have an increased risk of second tumor...
RNA binding by the Wilms tumor suppressor zinc finger proteins. Examines the effect of protein encoded by the Wilms tumor suppressor gene, WT1. Evidence of the gene product's ability to bind RNA; Zinc fingers of the pro... Caricasole,Andrea,Duarte,... - 《Proceedings of the National Academ...