Rate at which cells would progress from one state to the next by considering parameters such as mutation rate and the number of dominant CIN genes; Possibility that CIN to inactivate the first tumor-suppressor gene in colorectal cancer.doi:10.1038/nrc979None...
aThe P53 tumor suppressor gene product is a transcription factor involved in DNA repair. P53肿瘤遏抑器基因产品是在脱氧核糖核酸修理介入的副本因素。[translate] a他们的工作是城市清洁 Their work is the city is clean[translate] a他落后于其他同学 He falls behind other schoolmates[translate] ...
aThe P53 tumor suppressor gene product is a transcription factor involved in DNA repair. P53肿瘤遏抑器基因产品是在脱氧核糖核酸修理介入的副本因素。[translate] aDomini Research & Analytics (KLD) Social Ratings Database between 1991 and 2005.2 These[translate] ...
athis is a human tumor suppressor gene that cause adenomatous polyposis when it is mutated and these adenomatous polyposis are very easy developed to colorectal cancer. 这是导致腺瘤polyposis的一个人的肿瘤遏抑器基因,当它是变化的时,并且这些腺瘤polyposis是非常容易被开发对colorectal癌症。 [translate] a...
[2] Xueqian Gong, Jian Du, Stephen H Parsons, et al. Aurora-A kinase inhibition is synthetic lethal with loss of the RB1 tumor suppressor gene. Cancer Discov. 2019 Feb;9(2):248-263. [3] Khyati N Shah , Roma Bhatt, Julia Rotow, et al. Aurora Kinase A Drives the Evolution of Re...
So, under certain conditions, and if the number of dominantly acting CIN genes in the human genome exceeds a certain number, it should be possible for CIN to inactivate the first tumour- suppressor gene in colorectal cancer. The more time-consuming process — confirming this hypothesis — ...
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by mutations in the NF1 tumor suppressor gene, which affect approximately 1 out of ... W Lawrence - 《Cancer》 被引量: 531发表: 1993年 Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patien...
Hu YC, de Rooij DG, Page DC (2013) Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice. Proc Natl Acad Sci U S A 110(31):12685–12690 ArticleCAS Huckins C (1971) The spermatogonial stem cell population in adult rats. I. Their morphology, prolife...
aPTEN (phosphatase and tensin homolog deleted on chromosome ten), a recently discovered tumor suppressor gene, appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell proliferation and cell survival by dephosphorylating the phosphatidylinositol 3,4,5-triphosphate...
The tumour suppressor gene BAP1 was found to be recurrently mutated in UM with monosomy 3. Familial UM is rare and amounts to about 0.6–6% of all patients with melanoma. However, BAP1 germline mutations have been identified in rare hereditary tumour syndromes, including cases with UM. One ...