The nature of stem and progenitor cells in the mammary epithelium, and the relevance of cleared fat pad transplantation as a functional assay for them, has been thrown into doubt by recent lineage-tracking studies. Now two new studies based on tracking the progeny of Wnt-responsive cells are ...
Deletion of β-catenin or expression of stabilized β-catenin in these Axin2 -expressing cells results in abnormal development or oncogenic transformation, respectively. Our study uncovers a critical role of Wnt/β-catenin-responsive cells in prostatic development and regeneration, and that dysregulation...
Intestinal crypts contain Lgr5+ stem cells and their transit-amplifying (TA) daughter cells, as well as terminally differentiated Paneth cells. Cells exiting crypts terminally differentiate into enterocytes, goblet cells, M-cells, Tuft cells, and enteroendocrine cells and move up the flanks of the ...
Interestingly, cells capable of forming mammary organoids containing each cell type are identified within the luminal oestrogen receptor (ER)-negative cell population. Results Nrg1 mediated extended growth of mammary organoids. 3D culture conditions that allow the long-term maintenance of several ...
We thus measured RhoU mRNA in MEF cells stimulated with different WNT ligands, i.e. the canonical WNT1, the non-canonical WNT5a, and WNT4, which can activate both the canonical and the non-canonical Cancers 2019, 11, 101 3 of 17 pathway. Similar to WNT1, both WNT4 and WNT5a could ...
The skeletal muscle progenitor cells of the vertebrate body originate in the dermomyotome epithelium of the embryonic somites. To precisely locate myotome ... WF Denetclaw,B Christ,CP Ordahl - 《Development》 被引量: 342发表: 1997年 Control of Dorsoventral Somite Patterning by Wnt-1 and β-...
OBX-MMNs have the following features: i) MR/PA dual-modal imaging of MMNs holds more accurate diagnosis and imaging than single mode; ii) MMNs could generate hyperthermia upon laser irradiation to increase the accumulation of OBX in tumor cells/tissues; iii) pH-/NIR-induced drug release can ...
While it induced ectopic chondrogenesis in the RG, ablation of β‐catenin in the Wnt‐responsive cells strongly inhibited expansion of their descendants toward the growth plate. These findings indicate that the Wnt‐responsive cell population in the outermost layer of the growth plate is a unique ...
In the postnatal cochlea, the sensory epithelium is terminally differentiated, whereas tympanic border cells (TBCs) beneath the sensory epithelium are proliferative. The functions of TBCs are poorly characterized. Using an Axin2lacZ Wnt reporter mouse, we found transient but robust Wnt signaling and...
STEM CELLSHe, Y., Hooker, E., Yu, E.-J., Wu, H., Cunha, G. R. and Sun, Z. (2018). An indispensable role of androgen receptor in Wnt responsive cells during prostate development, maturation, and regeneration. Stem Cells 36, 891-902....